Predictive Value of Inflammation Biomarkers in Patients with Portal Vein Thrombosis

Background and Aims:To investigate the usefulness of inflammation biomarkers to serve as a predictors of portal vein thrombosis(PVT)postoperatively(post)in patients with portal hypertension after splenectomy and periesophagogastric devascularization.Methods:A total of 177 liver cirrhosis patients were recruited from January 2013 to December 2017.They were divided into a PVT group(n=71)and a non-PVT group(n=106),according to ultrasound examination findings at 7-day post.Inflammation biomarkers involving platelet-to-lymphocyte ratio(PLR),neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),red blood cell distribution width-to-platelet ratio(RPR),mean platelet volume-to-platelet ratio(MPR)preoperatively(pre)and at 1,3,7-days post were recorded.Results:The univariate logistic regression analysis indicated that PLR(pre)(odds ratio(OR)=3.963,95%confidence interval(CI)=2.070–7.587,p<0.000),MLR(pre)(OR=2.760,95%CI=1.386–5.497,p=0.004),PLR(postday 7)(OR=3.345,95%CI=1.767–6.332,p=0.000)were significantly associated with the presence of PVT.The multivariate logistic regression analysis results indicated that PLR(pre)(OR=3.037,95%CI=1.463–6.305,p=0.003),MLR(pre)(OR=2.188,95%CI=1.003–4.772,p=0.049),PLR(post-day 7)(OR=2.166,95%CI=1.053–4.454,p=0.036)were independent factors for predicting PVT.Conclusions:The PLR(pre),MLR(pre),and PLR(post-day 7)are predictors of portal vein thrombosis post in patients with portal hypertension after splenectomy and periesophagogastric devascularization.