青金栀汤治疗风寒闭肺证急性毛细支气管炎患儿的效果

Efficacy of Qingjinzhi Decoction in Treating Children with Wind-Cold Blocking Lung-Type Acute Bronchiolitis

目的研究青金栀汤治疗风寒闭肺证急性毛细支气管炎患儿的效果。方法选取2019年3月至2020年11月滑县人民医院风寒闭肺证急性毛细支气管炎患儿126例,依照随机数表法分为常规组(63例)、治疗组(63例)。常规组接受常规西医治疗,治疗组接受青金栀汤联合常规西医治疗。对比两组疗效、中医证候积分、肺功能[达峰容量比(VPEF/VE)、潮气量(VT)、达峰时间比(tPTEF/TE)]、血清嗜酸性粒细胞趋化因子11(CCL11)、巨噬细胞炎性蛋白1α(MIP-1α)、高敏C反应蛋白(hs-CRP)水平。结果治疗组总有效率[98.41%(62/63)]高于常规组[85.71%(54/63)](P<0.05);两组舌赤口干、咳嗽痰涎、憋喘气促、烦躁发热评分相比,治疗组低于常规组(P<0.05);治疗后,两组VT、tPTEF/TE、VPEF/VE高于治疗前,治疗组高于常规组(P<0.05);治疗后,两组血清CCL11、MIP-1α、hs-CRP水平低于治疗前,治疗组低于常规组(P<0.05)。结论青金栀汤治疗风寒闭肺证急性毛细支气管炎效果显著,可改善患儿临床症状,提高肺功能,机制可能与下调CCL11、MIP-1α、hs-CRP水平有关。

Objective To study the curative effect of Qingjinzhi Decoction in treating children with wind-cold blocking lung-type acute bronchiolitis.Methods From March 2019 to November 2020,126 children with wind-cold blocking lung-type acute bronchiolitis were selected from Huaxian People’s Hospital.According to the random number table method,they were divided into routine group(63 cases)and treatment group(63 cases).The conventional group was treated with conventional Western medicine,and the treatment group was treated with Qingjinzhi Decoction combined with conventional Western medicine.The efficacy,traditional Chinese medicine syndrome score,lung function[ratio of the volume to reach peak tidal expiratory flow to total expiratory time(VPEF/VE),volume tidal(VT),ratio of the time to reach peak tidal expiratiry flow to total expiratory time(tPTEF/TE)],CC chemokine ligand 11,eotaxin(CCL11),macrophage inflammatory protein 1α(MIP-1α),high sensitivity C-reactive protein(hs-CRP).Results The total effective rate of 98.41%(62/63)in the treatment group was higher than 85.71%(54/63)in the conventional group(P<0.05).The scores of red tongue,dry mouth,coughing,sputum and salivation,shortness of breath,breathlessness,irritability and fever of the treatment group were lower than the conventional group(P<0.05).After treatment,the VT,tPTEF/TE,VPEF/VE of the two groups were higher than those before treatment,and the treatment group were higher than the conventional group(P<0.05).After treatment,the two groups serum CCL11,MIP-1α,and hs-CRP levels were lower than before treatment,and the treatment group were lower than the conventional group(P<0.05).Conclusion Qingjinzhi Decoction is effective in treating wind-cold blocking lung-type acute bronchiolitis.It can improve the clinical symptoms and lung function of children.The mechanism may be related to the down-regulation of CCL11,MIP-1α,and hs-CRP levels.