摘要
Hepatitis B virus(HBV)is a small-enveloped virus enclosing a partially double-stranded DNA genome,belongs to the hepadnaviruses family.1 To date,10 genotypes(A–J)of HBV with distinct geographical distribution have been described,based on a divergence of at least 8%over the entire genomic sequence or>4%in the S gene sequence,with B and C being most prevalent and confined to Asia and Oceania.2 HBV is a highly contagious pathogen that can lead to acute infection or chronic hepatitis B(CHB),cirrhosis and hepatocellular carcinoma(commonly known as HCC)in humans through immune anergy or upon immunosuppression.
基金
RW was funded by the National Natural Science Foundation of China(82002130)
the Open Research Fund Program of the State Key Laboratory of Virology of China(2021IOV002)
ZX was funded by the National Natural Science Foundation of China(82072266)
the National Major Science&Technology Project for Control and Prevention of Major Infectious Diseases in China(2017ZX10103004-004).
