摘要
1-磷酸鞘氨醇(S1P)是一种具有生物活性的脂质介质,在人体内广泛表达,通过与不同部位的G蛋白耦联受体(S1PR1-5)结合,介导Ras/MEK/ERK、PI3K/AKT、PLC/IP3、Rho/NF-κB等信号通路参与多个生理病理过程;S1P及其受体的相互作用会影响气道、肺组织内的细胞增殖与迁移、凋亡,在炎症及免疫调节中也有重要作用,S1P参与哮喘、慢性阻塞性肺疾病、肺癌、肺纤维化、肺部感染、急性肺损伤等疾病的致病过程,拮抗S1P则带来积极影响,深入研究S1P可能为呼吸系统疾病提供治疗新靶点。
Sphingosine 1-phosphate(S1P)is a lipid mediator with biological activity,which is widely expressed in various tissues.Via combining with G-protein-coupled receptors(S1PR1-5)in different tissues,S1P can regulate Ras/MEK/ERK,PI3K/AKT,PLC/IP3,Rho/NF-κB and other signaling pathways and mediate various physiological and pathological reactions.The interaction of S1P and its receptors can affect the proliferation,migration and apoptosis of cells in airway and lung tissue,and it also plays an important role in inflammation and immune regulation.S1P mediates the pathogenic process of diseases such as asthma,chronic obstructive pulmonary disease,lung cancer,pulmonary fibrosis,pulmonary infection and acute lung injury,while antagonizing S1P could relieve symptoms and delay the development of these diseases.Further study of S1P may provide a new therapeutic target for respiratory diseases.
作者
蒋艳
张韶泽
曾丹
朱黎明
Jiang Yan;Zhang Shaoze;Zeng Dan;Zhu Liming(Department of Respiratory and Critical Care Medicine,Hunan Provincial People′s Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha 410016,China;Hunan Institute of Geriatrics,Hunan Provincial People′s Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha 410016,China)
出处
《中国医师杂志》
CAS
2021年第12期1909-1913,共5页
Journal of Chinese Physician
基金
湖南省科技创新计划项目(2017SK50522)
湖南省卫生健康委2020年度科研立项课题(20201498)
长沙市新型冠状病毒感染的肺炎疫情应急专题科技计划项目(kq2001018)
湖南省保健专项资金科研课题(B2020-01)。
关键词
呼吸道疾病
磷酸鞘氨醇-1
信号通路
Respiratory tract diseases
Sphingosine 1-phosphate
Signaling pathway
