血小板/淋巴细胞比值对干燥综合征疾病活动程度的评估价值

Value of platelet/lymphocyte ratio in evaluating disease activity of Sjogren’s syndrome

目的:探讨血小板/淋巴细胞比值(PLR)对干燥综合征(SS)疾病活动程度的评估价值。方法:采用欧洲抗风湿联盟SS疾病活动性评估指数(ESSDAI)进行疾病活动度评估,并将92例SS患者分为活动组(ESSDAI>4分,n=43)和稳定组(ESSDAI≤4分,n=49)。比较两组患者一般资料和实验室相关指标,采用Speraman相关分析PLR与SS疾病活动指标的相关性,绘制受试者工作特征(ROC)曲线分析PLR对SS患者疾病活动度的评估诊断价值。结果:活动组红细胞沉降率(ESR)、C-反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)和PLR均高于稳定组,差异有统计学意义(P<0.05)。SS患者PLR与ESSDAI评分、ESR、CRP、IgA、IgG均呈正相关(r=0.683、0.579、0.590、0.438、0.501,P<0.05)。ROC曲线分析显示,PLR评估诊断SS患者疾病活动度的ROC曲线下面积(AUC)为0.728(95%CI:0.603~0.853),最佳截断值为167.50,敏感度为65.12%,特异度为73.47%。结论:PLR与SS患者病情活动度密切相关,具有辅助诊断价值。

Objective:To investigate the value of platelet/lymphocyte ratio(PLR) in evaluating the disease activity of Sjogren’s syndrome(SS).Methods:92 patients with SS were evaluated by the European anti rheumatism alliance SS disease activity assessment index(essdai),and were divided into 43 cases in the active group(ESSDAI>4 score) and 49 cases in the stable group(ESSDAI≤4 score).The general data and laboratory related indexes of the two groups were compared.The correlation between PLR and SS disease activity indexes was analyzed by Sperman correlation,and the receiver operating characteristic(ROC) curve was drawn to analyze the evaluation and diagnostic value of PLR on SS patients’ disease activity.Results:The erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),immunoglobulin A(IgA),immunoglobulin G(IgG) and PLR in the active group were significantly higher than those in the stable group(P<0.05).PLR was positively correlated with ESSDAI score,ESR,CRP,IgA and IgG(r=0.683,0.579,0.590,0.438,0.501,P<0.05).ROC curve analysis showed that the area under the curve(AUC) of PLR in the evaluation and diagnosis of disease activity in SS patients was 0.728(95% CI:0.603~0.853),the best cut-off value was 167.50,the sensitivity was 65.12%,and the specificity was 73.47%.Conclusion:PLR is closely related to the disease activity of SS patients,and has auxiliary diagnostic value for clinical disease diagnosis.