肠道菌群及其代谢产物作为阿尔茨海默病诊断生物标志物的研究进展

Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是老年期痴呆最常见的一种类型,随着"脑-肠轴"理论的提出,越来越多的研究证实AD的发生发展与肠道菌群构成及其代谢产物的改变密切相关。本文就近年肠道菌群及其代谢产物在AD领域的研究进行综述和讨论,以此为着眼点,阐述以粪便为标本的肠道菌群及其代谢产物检查作为AD诊断生物标志物的应用前景。

Alzheimer’s disease(AD)is the main cause of senile dementia.With the proposal of the“brain-gut axis”theory,more and more studies have confirmed the occurrence and development of AD are closely related to the change of gut microbiota and its metabolites.This article reviews and discusses the changes of fecal gut microbiota and its metabolites occurred in AD.Besides,the application prospects of fecal gut microbiota and its metabolites as AD diagnostic biomarkers are described.