丁酸钠在代谢相关脂肪性肝病中的研究进展

Research progress of sodium butyrate in metabolic-associated fatty liver disease

代谢相关脂肪性肝病(MAFLD)已成为影响全世界公众健康最常见的慢性肝病,发病率呈逐年上升趋势。其发病的分子机制尚不完全清楚,且临床缺乏有效的防治手段。研究发现丁酸钠在体内能够参与基因调控、免疫调节、肠道屏障功能调节、氧化应激等多种生理活动,可预防和缓解MAFLD,其在MAFLD的发生、发展过程中起着重要作用。现就丁酸钠对MAFLD的基因表达调控、改善脂肪代谢、调节肠道菌群及改善脂肪性肝炎等相关研究进行综述。

Metabolic-associated fatty liver disease(MAFLD)has become the most common chronic liver disease affecting global public health,and its incidence rate is increasing year by year.The molecular mechanism of its pathogenesis is not yet fully understood,and there is a shortage of effective clinical prevention and treatment methods.Studies have found that sodium butyrate can participate in gene regulation,immune regulation,intestinal barrier function regulation,oxidative stress and other in-vivo physiological activities.Furthermore,it also plays an important role in preventing and alleviating the MAFLD occurrence and development.This article reviews the related studies of sodium butyrate on gene expression regulation,fat metabolism improvement,intestinal flora regulation,and steatohepatitis improvement with MAFLD.