摘要
为改善海藻酸钙(calcium alginate,CA)支架材料的力学性能,本研究在海藻酸盐支架体系中引入了具有良好力学性能的天然丝素蛋白分子(silk fibroin,SF),创新性地通过钙离子迁移带动SF在海藻酸盐体系中分散的方式,构建了一种具有“钢筋混凝土”结构的SF/CA支架。通过对支架材料进行成份、结构和性能的研究,结果表明,该新型丝素蛋白/海藻酸钙多孔支架材料相比于传统海藻酸钙支架,具有更优的力学性能。该支架有可能为组织工程材料提供一种新的选择。
To improve the technical properties of calcium alginate(CA)scaffold material,we introduced natural silk fibroin(SF)moleculewith good regenerative properties into the alginate system,and innovatively constructed a SF/CA scaffold with"reinforced concrete"structureby driving SF to disperse in the alginate system through calcium ion migration.The content,structure and properties of the scaffoldmaterial were studied.The results showed that the preparation of the new SF/CA porous scaffold material had better mechanical properties than that of the traditional CAscaffold.This meterailmay provide a new choice for tissue engineering materials.
作者
吴秋惠
丁硕秋
任天
徐睿婷
周超
赵宝洲
邓林红
刘杨
WU Qiuhui;DING Shuoqiu;REN Tian;XU Ruiting;ZHOU Chao;ZHAO Baozhou;DENG Linhong;LIU Yang(School of Materials Science and Engineering,Changzhou University,Changzhou 213164,China;Institute of Biomedical Engineering and Health Sciences,Changzhou University,Changzhou 213164)
出处
《生物医学工程研究》
2021年第4期389-394,共6页
Journal Of Biomedical Engineering Research
基金
国家自然科学基金资助项目(81900814)
浙江省重点研发计划项目(2020C03003)
江苏省自然科学基金资助项目(BK20180963、BK20171196)。
关键词
丝素蛋白
海藻酸钠
离子迁移
海藻酸钙
多孔支架
“钢筋混凝土”结构
力学性能
组织工程
Silk fibroin
Sodium alginate
Ion migration
Calcium alginate
Porous scaffold
"Reinforced concrete"structure
Mechanical properties
Tissue engineering
