m^(6)A RNA甲基化修饰在常见心血管疾病和心肌肥大中的研究进展

Research progress on N6-methyladenosine RNA modification in common cardiovascular diseases and cardiac hypertrophy

心血管疾病是影响全球伤残调整生命年和导致死亡的主要原因。最近研究报道,mRNA最普遍的内部修饰N6-腺苷酸甲基化(m^(6)A)在心血管疾病中发挥重要作用。本文概述了m^(6)A RNA甲基化修饰的关键酶及动态调节过程,重点阐述了m^(6)A RNA甲基化在心肌肥大和心力衰竭、高血压、冠状动脉粥样硬化性心脏病、心律失常等常见心血管疾病中的研究进展,并对m^(6)A RNA甲基化新技术进行了讨论。

Cardiovascular diseases are the main cause of global disability-adjusted life years and death.The most common post-transcriptional mRNA modification is that of N6-methyladenosine(m^(6)A),which has an important role in cardiovascular diseases.This review summarizes key enzymes and the dynamic regulation process of m^(6)A RNA modification.We also focus on the research progress of m^(6)A RNA modification with respect to its role in cardiac hypertrophy,heart failure,hypertension,coronary heart disease,and arrhythmia.Finally,we discuss a new mechanism of m^(6)A RNA modification.