摘要
遗传背景的差异会导致不同人群对同一种药物产生药物效应差异。随着药物基因组学的研究与发展,探讨药物基因组学与群体遗传差异的关系有助于阐明药物代谢相关基因多态性在中国不同人群药物效应异质性中的重要作用。本文总结了常见药物代谢相关基因多态性在中国不同人群中的研究情况,旨在为中国不同人群的个体化治疗提供有价值的理论依据。
Genetic background can lead to differences in drug effects among different populations when they use the same drug.To delineate the pharmacogenomics and population genetic differences may help to clarify the role of polymorphisms of drug metabolism-related genes in drug effect heterogeneity among different populations.This article has summarized the latest progress on the polymorphisms of drug metabolism-related genes among different populations in China.
作者
张婷婷
董博南
李秋炎
傅松滨
Zhang Tingting;Dong Bonan;Li Qiuyun;Fu Songbin(Laboratory of Medical Genetics,Key Laboratory of the Ministry of Kducation for the Preservation of Human Genetic Resources and Disease Control in China,Harbin Medical University,Harbin,Heilongjiang 150081,China)
出处
《中华医学遗传学杂志》
CAS
CSCD
2022年第1期108-111,共4页
Chinese Journal of Medical Genetics
关键词
药物代谢
单核苷酸多态性
中国人群
Drug metabolism
Single nucleotide polymorphism
Chinese population
