顶复门原虫感染与宿主细胞自噬相互作用的研究进展

Research progress on the interaction between host cell autophagy and apicomplexa protozoa infection

细胞自噬是一种保守的、广泛存在于真核生物中的溶酶体依赖性的降解系统,细胞内物质通过该机制运送至溶酶体内进行降解,对处于饥饿、缺氧等应激条件下的细胞生存发挥着重要作用。此外,细胞也可以通过自噬的清除作用消灭外来病原体如寄生虫、病毒等。顶复门原虫是一类专性细胞内寄生原虫,多为人兽共患病病原,对社会公共卫生带来较大的威胁。近年来关于细胞自噬和顶复门原虫之间的相互影响的研究进展主要集中在弓形虫和疟原虫。本文对自噬机制、自噬与重要顶复门原虫感染的相互作用研究进展进行综述。

Autophagy is a conserved lysosome-depenendant degradation system widely present in eukaryotes,and intracellular substances are transported to lysosomes for degradation through this mechanism,which plays an important role in cell survival under stress conditions of starvation and hypoxia.In addition,cells can also eliminate foreign pathogens such as parasites and viruses through the clearance action of autophagy.Apicomplexa protozoa are obligatory intracellular parasites,often zoonotic pathogens,posing considerable threats to social development and public health.In recent years,researches on the interaction between autophagy and apicomplexa protozoa mainly focused on Toxoplasma gondii and Plasmodium.In this paper,we reviewed the progress of research on the interaction between autophagy and important Apicomplexa protozoa infection.