香豆素类化合物抗肿瘤机制的研究进展

Research progress in anti-cancer mechanism of coumarins

香豆素类化合物是传统的中草药成分,在自然界中普遍存在。近年来,其抗肿瘤作用得到了广泛的关注。研究表明,香豆素类化合物可通过诱导肿瘤细胞凋亡、阻滞细胞分裂周期、抑制肿瘤血管生成及肿瘤细胞迁移和侵袭、抗氧化以及调控多种蛋白和酶的活性等机制发挥抗肿瘤作用。本文综述了近年来香豆素类化合物抗肿瘤机制的研究进展,以期为香豆素类化合物的进一步研究和开发提供理论基础和依据。

Coumarins are traditional herbal ingredients that are commonly found in nature.In recent years,their anti-tumor effects have received widespread attention.Researches have shown that coumarins exert anti-tumor effects through inducing apoptosis,blocking cell cycle,inhibiting tumor angiogenesis,tumor cell migration and invasion and antioxidation,and regulating the activities of various proteins and enzymes.This article reviews the recent research progress in the anti-tumor mechanism of coumarins so as to provide theoretical basis for the further research and development of coumarins.