养血通络醒脑汤治疗痰瘀阻络型中风恢复期临床观察

Clinical Observation on Yangxue Tongluo Xingnao Decoction in the Treatment of Phlegm Stasis Blocking Collateral Type Stroke in the Recovery Period

目的探讨养血通络醒脑汤治疗痰瘀阻络型中风恢复期的临床效果。方法依据随机数字表法将2018年12月—2020年1月收取的68例确诊为痰瘀阻络型中风恢复期患者随机分为对照组和研究组各34例。对照组采用常规治疗,研究组在常规治疗基础上给予养血通络醒脑汤治疗。2个月后,比较2组患者临床疗效、中医证候积分、NIHSS评分、Barthel指数评分、血清TNF-α、hs-CRP及IL-4水平。结果治疗后,研究组临床总有效率为91.18%,明显高于对照组的73.53%(P<0.05);治疗后2组患者的中医证候积分均有所下降且研究组下降更明显(P<0.05);治疗后2组患者的NIHSS评分、Barthel指数评分均有所改善且研究组更明显(P<0.05);治疗后2组患者血清的TNF-α、hs-CRP及IL-4水平均有所下降,但研究组效果更优(P<0.05)。结论养血通络醒脑汤治疗痰瘀阻络型中风恢复期患者具有良好效果,可有效缓解患者临床症状,并降低患者血清TNF-α、hs-CRP及IL-4水平,可考虑进一步临床推广、使用。

Objective To explore the clinical effect of Yangxue Tongluo Xingnao decoction in the treatment of phlegm stasis blocking collateral type stroke in the recovery period.Methods According to the random number table method,68 patients who were diagnosed with phlegm stasis blocking collateral type stroke in the recovery period in our hospital from December 2018 to January 2020 were randomly divided into a control group and a study group,with 34 cases in each group.The control group was treated with conventional treatment.The study group was treated with Yangxue Tongluo Xingnao decoction on the basis of conventional treatment.Two months later,the clinical efficacy,traditional Chinese medicine syndrome score,NIHSS score,Barthel Index score,serum TNF-α,hs-CRP,and IL-4 were compared between the two groups.Results After treatment,the total clinical onset rate in the study group was 91.18%,which was significantly higher than 73.53% in the control group(P< 0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups of patients decreased and the study group decreased more significantly(P< 0.05);After treatment,the NIHSS score and Barthel Index score of the two groups were improved and the study group was more obvious(P< 0.05).The serum levels of TNF-α,hs-CRP,and IL-4 in the two groups after treatment all decreased,but the effect of the study group was better(P< 0.05).Conclusion Yangxue Tongluo Xingnao decoction has a good effect in the treatment of patients with phlegm stasis obstructing collaterals at the recovery stage,which can effectively relieve the clinical symptoms of the patients and reduce the serum TNF-α,hs-CRP,and IL-4 levels of the patients.Further clinical considerations can be considered promotion and use.