督灸对气虚质功能性便秘患者焦虑抑郁状态及5-羟色胺的影响

Effect of Du-moxibustion on Anxiety,Depression and 5-hydroxytryptamine in Patients with Functional Constipation of Qi Deficiency Constitution

目的探讨督灸对气虚质功能性便秘患者焦虑抑郁状态及5-羟色胺的影响。方法80例气虚质功能性便秘患者随机分为督灸组、西药组。督灸组每10 d治疗1次,3次为一个疗程,共治疗2个疗程;西药组口服乳果糖口服液治疗,每日3次,每次10 ml,30 d为一个疗程,共治疗2个疗程。比较治疗前后患者体质转化分、焦虑自评量表(SAS)积分、抑郁自评量表(SDS)积分及5-羟色胺(5-HT)水平的变化。结果治疗2个疗程后,督灸组总有效率为90.0%,西药组80.0%。督灸组气虚体质转化分较治疗前显著下降(P<0.05),西药组气虚体质转化分变化差异无统计学意义(P>0.05)。组内比较,2组患者SAS、SDS积分均较治疗前下降,5-HT水平较治疗前上升,差异具有统计学意义(P<0.05);组间比较,督灸组SAS、SDS及5-HT变化水平均高于西药组,差异具有统计学意义(P<0.05)。结论督灸可通过改善SAS、SDS以及5-HT水平对气虚质功能性便秘起治疗作用,疗效优于西药治疗;督灸还能纠正患者气虚体质偏颇状态,提升患者健康状况,可作为中医绿色疗法推广。

Objective To explore the effect of du-moxibustion on anxiety,depression and 5-hydroxytryptamine in patients with functional constipation of qi deficiency constitution.Methods Total 80 patients with functional constipation of qi deficiency were randomly divided into the treatment group and the control group,with 40 cases in each group.Subjects in the treatment group were treated with du-moxibustion once every ten days.Each patient totally received six times.Subjects in the control group were treated with lactulose oral solution,10ml each time,three times every day,taking 60 days,Syndrome scores,SDS scores,SAS scores and 5-HT were observed before and after the treatment.Results After treatment,the total effective rate in the treatment group was 90.0%,and that of the control group was 80.0%.The symptom scores decreased in the treatment group(P<0.05),while the control group had no significant difference before and after treatment(P>0.05).Intra-group comparisons,the SDS scores and SAS scores in the treatment group decreased significantly compared with before treatment,and the 5-HT was raised(P<0.05).The intergroup comparison,the SDS scores,SAS scores and 5-HT in the treatment group decreased significantly compared with the control group(P<0.05).Conclusion Du moxibustion can treat functional constipation of qi deficiency constitution by regulating the contents of the SDS scores,SAS scores and 5-HT,and the curative effect is better than that of western medicine.Du-moxibustion can improve the physical bias and anxiety state of the patients with functional constipation of qi deficiency constitution,thus improving the health status of the subjects,which can be promoted as a green therapy of traditional Chinese medicine.