大血管闭塞急性缺血性脑卒中超时间窗机械取栓研究现状

Mechanical thrombectomy for acute ischemic stroke with large vessel occlusion beyond time window:current status

血管再通治疗是大血管闭塞急性缺血性脑卒中(AIS-LVO)最主要的治疗方式。研究证实AIS-LVO机械取栓的明确时间窗为发病6 h内,对于发病6~24 h或超过24 h接受机械取栓的患者筛选仍存争议。本文对发病或末次正常时间为6~24 h的超时间窗AIS-LVO患者和超出24 h的超晚期AIS-LVO患者的机械取栓治疗现状进行总结,并分析延长取栓时间窗的可行性和评估策略。

Vascular recanalization therapy is the major treatment strategy for acute ischemic stroke with large vessel occlusion(AIS-LVO).Time window for mechanical thrombectomy has been proven to be within 6 h after stroke onset.Screening of patients who are to undergo mechanical thrombectomy 6-24 h or beyond 24 h after onset remains controversial.In this review,we summarize the current status of mechanical thrombectomy in AIS-LVO patients with extended time window of6-24 h or beyond 24 h,and analyze the feasibility and evaluate the strategies for extending the time window of thrombectomy.