基于代谢组学技术探讨高尿酸血症合并慢性肾脏疾病的研究进展

Research progress of chronic kidney disease with hyperuricemia based on metabolomics

代谢组学具有灵敏、快速、高通量的特点,在研究内源性小分子的变化规律、发现异常代谢物、揭示个体代谢表征等方面具有应用潜力。利用代谢组学研究高尿酸血症合并慢性肾脏疾病是近年来的热点。对高尿酸血症合并慢性肾脏疾病的相关代谢组学的研究表明,该病与氨基酸、脂质代谢紊乱密切相关。就代谢组学在高尿酸血症合并慢性肾脏疾病发病机制探索、生物标志物筛选、中药治疗方面的应用展开综述。

Metabolomics is sensitive,fast,and high-throughput.It has application potential in studying the changing laws of endogenous small molecules,discovering abnormal metabolites,and revealing individual metabolic characteristics.Metabonomics has become a hot topic in the study of hyperuricemia combined with chronic kidney disease in recent years.Related metabonomics studies of hyperuricemia combined with chronic kidney disease show that the disease is closely related to the disorder of amino acid and lipid metabolism.This paper reviews the application of metabonomics in pathogenesis exploration,biomarker screening and Chinese herbal treatment of hyperuricemia combined with chronic kidney disease.