围绝经期妇女性激素水平与睡眠质量的相关性分析

Correlation Analysis of Sex Hormone Levels and Sleep Quality in Perimenopausal Women

目的探究围绝经期妇女性激素水平与睡眠质量的相关性。方法选择纳入我院2018年10月至2020年9月收治的围绝经期女性82例,依据匹兹堡睡眠质量指数(PSQI)状况进行分组,将PSQI评分≥8分纳入睡眠质量差组(44例),另将PSQI评分≤7分纳入睡眠质量尚可组(38例)。采集所有患者清晨空腹静脉血,离心处理后获得上层血清。比较两组性激素[促黄体素(LH)、卵泡刺激素(FSH)、睾酮(T)、促甲状腺激素(TSH)、雌二醇(E_(2))]水平,进一步分析性激素水平与睡眠质量的相关性。结果睡眠质量尚可组T、E_(2)、TSH水平高于睡眠质量差组,FSH、LH水平低于睡眠质量差组,差异有统计学意义(P<0.05);T、E_(2)、TSH与睡眠质量差患者呈负相关(r=-0.71、-0.80、-0.72,P=0.001、0.005、0.004),FSH及LH睡眠质量差患者呈正相关(r=0.46、0.40,P=0.002、0.003)。以睡眠质量(0=差,1=可)为因变量,以单因素分析中差异有统计学意义的5项因素为自变量进行非条件Logistic回归分析,结果显示T(OR=-0.353,95%CI:0.354~1.275)、E_(2)(OR=-0.432,95%CI:0.182~0.951)、TSH(OR=-0.291,95%CI:0.252~1.135)、FSH(OR=4.035,95%CI:1.354~5.985)和LH(OR=3.425,95%CI:1.582~6.025)是主要影响围绝经期妇女性睡眠质量的性激素指标。结论围绝经期女性性激素水平与睡眠质量间存在相关性,多个性激素指标是影响患者睡眠质量的因素,临床上需依据性激素检查情况给予针对性干预。

Objective To explore the correlation between sex hormone levels and sleep quality in perimenopausal women.Methods Eighty-two perimenopausal women admitted to our hospital from October 2018 to September 2020 were divided into groups according to Pittsburgh Sleep Quality Index(PSQI).PSQI score≥8 were included in the poor sleep quality group(44 cases),and PSQI score≤7 was included in the fair sleep quality group(38 cases).Early morning venous blood was collected from all patients after fasting,and upper serum was obtained after centrifugation.The levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),thyroid stimulating hormone(TSH)and estradiol(E_(2))were compared between the two groups,and the correlation between the levels of sex hormones and sleep quality was analyzed.Results The levels of T,E_(2) and TSH in fair sleep group were higher than those in poor sleep quality group,while the levels of FSH and LH were lower than those in poor sleep quality group,the difference was statistically significant(P<0.05).T,E_(2),TSH were negatively correlated with poor sleep quality(r=-0.71,-0.80,-0.72,P=0.001,0.005,0.004),while FSH and LH were positively correlated with poor sleep quality(r=0.46,0.40,P=0.002,0.003).The sleep qualiy(0=poor,1=well)was taken as the dependent variable,and the 5 factors with statistically significant differences in univariate analysis were taken as independent variables to perform conditional Logistic regression analysis.The results showed T(OR=-0.353,95%CI:0.354-1.275),E_(2)(OR=-0.432,95%CI:0.182-0.951),TSH(OR=-0.291,95%CI:0.252-1.135),FSH(OR=4.035,95%CI:1.354-5.985)and LH(OR=3.425,95%CI:1.582-6.025)affect the sex hormone indicators of perimenopausal women's sex sleep quality.Conclusion There is a correlation between sex hormone level and sleep quality in perimenopausal women.Multiple sex hormone indexes are the factors affecting sleep quality of patients.