乌灵胶囊对卒中后癫痫病人炎性因子及氧化应激水平的影响

Effect of Wuling capsule on inflammatory factor and oxidative stress level in post-stroke epilepsy patients

目的探讨乌灵胶囊对卒中后癫痫(PSE)病人的疗效、炎性因子、氧化应激及神经细胞因子水平的影响。方法回顾性分析2015年12月至2018年12月宜宾市第一人民医院收治的120例PSE病人的临床资料,按治疗方法不同分为观察组与对照组,各60例。对照组口服左乙拉西坦片治疗,观察组在对照组基础上加用乌灵胶囊口服,两组均连续治疗6个月。治疗后,比较两组临床疗效、血清炎性因子、氧化应激及神经细胞因子水平。结果治疗后,观察组总有效率高于对照组(91.67%比76.67%,P<0.05);观察组IL-1β、IL-6、IL-8、TNF-α水平[(12.32±4.40)比(17.51±5.39)pg/mL,(15.68±4.66)比(21.46±4.57)pg/mL,(10.57±4.53)比(16.36±4.96)pg/mL,(19.90±4.51)比(29.73±5.86)pg/mL]低于对照组(P<0.05);观察组SOD、GSH-Px水平[(129.15±11.42)比(97.21±9.12)U/mL,(78.50±9.06)比(59.11±6.96)U/L]高于对照组,观察组MDA、MPO水平[(6.43±1.28)比(10.82±1.24)nmol/mL,(422.87±105.69)比(539.29±116.09)U/L]低于对照组(P<0.05);观察组NSE、S100B[(6.22±1.23)比(8.38±1.58)ng/mL,(0.13±0.03)比(0.21±0.08)ng/mL]低于对照组(P<0.05),观察组BDNF[(26.23±4.31)比(22.90±4.48)ng/mL]高于对照组(P<0.05)。结论乌灵胶囊辅助治疗PSE,可提高治疗有效率,且能明显减少病人炎性因子释放及降低氧化应激水平并减轻神经损伤。

Objective To explore the effect of Wuling capsule on the curative effect,inflammatory factors,oxidative stress and the level of neurocytokines in patients with post stroke epilepsy(PSE).Methods The clinical data of 120 patients with PSE in the First People's Hospital of Yibin from December 2015 to December 2018 were analyzed retrospectively.According to different treatment methods,the patients were divided into observation group and control group,with 60 cases in each group.The control group was treated with levetiracetam.The observation group was treated with Wuling capsule on the basis of the control group.Both groups were treated continuously for 6 months.After treatment,the clinical efficacy,serum inflammatory factors,oxidative stress levels and neurocytokine factors were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group(91.67%vs.76.67%,P<0.05).The levels of IL-1β,IL-6,IL-8 and TNF-αin the observation group[(12.32±4.40)vs.(17.51±5.39)pg/mL,(15.68±4.66)vs.(21.46±4.57)pg/mL,(10.57±4.53)vs.(16.36±4.96)pg/mL,(19.90±4.51)vs.(29.73±5.86)pg/mL]were lower than those in the control group(P<0.05).The levels of SOD and GSH-Px in the observation group[(129.15±11.42)vs.(97.21±9.12)U/mL,(78.50±9.06)vs.(59.11±6.96)U/L]were higherthan those in the control group,and the levels of MDA and MPO in the serum[(6.43±1.28)vs.(10.82±1.24)nmol/mL,(422.87±105.69)vs.(539.29±116.09)U/L]were lower than those in the control group(P<0.05).The levels of NSE,S100B in the observation group[(6.22±1.23)vs.(8.38±1.58)ng/mL,(0.13±0.03)vs.(0.21±0.08)ng/mL]were lower than those in the control group,and the level of BDNF[(26.23±4.31)vs.(22.90±4.48)ng/mL]were higher than those in the control group(P<0.05).Conclusion The adjuvant treatment of PSE with Wuling Capsule can improve the treatment efficiency,and significantly reduce the release of inflammatory factors,the leveloxidative stress and nerve damage.