摘要
目的:观察完柴汤结合阿莫西林克拉维酸钾治疗复发性泌尿道感染临床疗效及安全性。方法:研究纳入105例发性泌尿道感染患者,均由我院2018年9月~2019年8月收治,采取随机数字表法将其分为两组,予以对照组患者(52例)阿莫西林克拉维酸钾治疗,予以观察组患者(53例)完柴汤结合阿莫西林克拉维酸钾治疗,比较临床疗效、治疗前后中医症状(尿频尿急尿痛、小腹坠胀、腰腹疼痛、头晕乏力、面足浮肿、舌质淡等)积分变化、治疗前患者血清C反应蛋白(CRP)水平及白介素-6(IL-6)水平,随访1年比较两组患者治疗后6个月及12个月复发率情况。结果:观察组患者治疗总有效率(98.11%)高于对照组(86.54%),P<0.05;治疗前,两组患者尿频尿急尿痛、小腹坠胀、腰腹疼痛、头晕乏力、面足浮肿、舌质淡等中医症状积分、CRP及IL-6水平比较,P>0.05,治疗后各组患者尿频尿急尿痛、小腹坠胀、腰腹疼痛、头晕乏力、面足浮肿、舌质淡等中医症状积分、CRP及IL-6水平指标均改善,观察组患者治疗后尿频尿急尿痛、小腹坠胀、腰腹疼痛、头晕乏力、面足浮肿、舌质淡等中医症状积分、CRP及IL-6水平指标均优于对照组,P<0.05;观察组患者6个月复发率与对照组相当,P>0.05,观察组患者12个月后复发率(0.00%)低于对照组患者(7.69%),P<0.05。结论:完柴汤结合阿莫西林克拉维酸钾治疗复发性泌尿道感染临床疗效显著,患者症状改善,血清炎症因子水平降低,不良反应率降低,1年复发率低,安全可靠,值得应用。
Objective: To explore the clinical efficacy and safety research of using Wanchai Decoction combined with amoxicillin clavulanic potassium in the treatment of recurrent urinary tract infection.Methods: In this study, 105 patients with recurrent urinary tract infection were admitted to our hospital from September 2018 to August 2019.They were divided into two groups by random number table method.Patients in the controlled group(52 cases) were treated with amoxicillin clavulanate, while patients in the observation group(53 cases) were treated with Wencai Decoction combined with amoxicillin clavulanate.Compared the clinical effect of traditional Chinese medicine(TCM),before and after treatment, the symptoms(pain, frequent urination urgency urine alvine the belly, waist and abdomen pain, dizziness, fatigue, face foot edema, pale tongue, etc.) changes, with patients before treatment serum C-reactive protein(CRP) level and interleukin 6(IL-6) levels, adverse reactions, followed up for 1 year, comparing two groups of patients with recurrence 6 months and 12 months after treatment.Results: The total effective rate(98.11%) in the observation group was higher than that in the controlled group(86.54%),P<0.05.Before the treatment, the two groups of patients with frequent urination urgency urinary pain, stomach and belly, waist and abdomen pain, dizziness, weakness, planes foot edema, pale tongue, Chinese medicine symptom integral, CRP and IL-6 horizontal comparison, P > 0.05,groups of patients after treatment with frequent urination urgency urinary pain, the lower abdomen and the belly, waist and abdomen pain, dizziness, weakness, planes foot edema, pale tongue, Chinese medicine symptom integral, CRP and level of IL-6 indexes were improved, the observation group after treatment with frequent urination urgency urinary pain, the lower abdomen and the belly, waist and abdomen pain, dizziness, weakness, planes foot edema, pale tongue, TCM symptoms integral, CRP and level of IL-6 indicators were superior to the controlled group, P<0.05.The recurrence rate of patients in the observation group at 6 months was similar to that in the controlled group(P>0.05),and the recurrence rate of patients in the observation group at 12 months(0.00%) was lower than that in the controlled group(7.69%),P<0.05.Conclusion: Wanchai Decoction combined with amoxicillin clavulanate potassium in the treatment of recurrent urinary tract infection has a significant clinical effect.The symptoms of the patients have been improved, the level of serum inflammatory factors has been reduced, the rate of adverse reactions has been reduced, and the recurrence rate of 1 year is low.It is safe and reliable, and worthy of application.
作者
张熙
王宪赟
王怡
ZHANG Xi;WANG Xianyun;WANG Yi(Department of Nephrology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Attached to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《四川中医》
2021年第12期142-145,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
复发性泌尿道感染
完柴汤
阿莫西林克拉维酸钾
临床疗效
复发率
Recurrent urinary tract infection
Wanchai Decoction
Potassium amoxicillin clavulanic acid
Clinical efficacy
Recurrence rate