刮痧联合隔姜灸提高大肠癌化疗后免疫功能临床研究

Clinical Study of Scraping Therapy Combined with Ginger-separated Moxibustion for Improve Immune Function after Chemotherapy of Colorectal Cancer

目的:观察刮痧联合隔姜灸对大肠癌化疗后疗效、免疫功能及肠道菌群的影响。方法:对我院住院部2020年3月~2021年3月收治的86例患者为研究对象,所有患者均行FOLFOX-7治疗方案,随机分为对照组及观察组各43例,对照组予常规护理,观察组予铜砭刮痧联合穴位隔姜灸中医特色护理,观察两组疗效、免疫功能及肠道菌群。结果:(1)观察组临床治愈率83.7%显著优于对照组69.8%(P<0.05);(2)治疗后,观察组中医证候各个单积分及积分均显著下降(P<0.05),且观察组显著低于对照组(P<0.05);(3)治疗后,观察组免疫功能各指标均显著高于对照组(P<0.05);(4)治疗后,观察组肠道大肠杆菌、肠球菌数量较前下降,且显著低于对照组(P<0.05),乳酸杆菌、双歧杆菌及sIgA较前升高,且显著高于对照组(P<0.05)。结论:铜砭刮痧联合隔姜灸能显著提高大肠癌化疗后临床疗效,其机制可能与调节肠道菌群及免疫应答,保护肠道屏障,改善免疫功能,增强抗病能力有关。

Objective: To explore the effect of scraping therapy combined with ginger-separated moxibustion for improving the efficacy, immune function and intestinal flora of colorectal cancer after chemotherapy.Methods: The 86 patients admitted to the inpatient department of our hospital from March 2020 to March 2021 were the subjects of the study.All patients were treated with FOLFOX-7 and randomly divided into a controlled group and an observation group with 43 cases each.The controlled group received routine care and the observation group was treated with Tongbian scraping and acupoint-separated moxibustion with traditional Chinese medicine characteristic nursing care.Observation of the efficacy, immune function and intestinal flora of the two groups.Results:(1)The clinical cure rate of the observation group was 83.7% significantly better than that of the controlled group 69.8%(P<0.05);(2)After treatment, the individual scores and points of TCM syndromes in the observation group decreased significantly(P<0.05),and the observation group was significantly lower than the controlled group(P<0.05);(3)After treatment, the immune function indexes of the observation group were significantly higher than those of the controlled group(P<0.05);(4)After treatment, the number of intestinal Escherichia coli and Enterococcus in the observation group decreased and significantly lower than the controlled group(P<0.05),Lactobacillus, Bifidobacterium and sIgA were higher than before, and were significantly higher than the controlled group(P<0.05).Conclusion: Combination of scraping therapy with Copper Bianstone and ginger moxibustion can significantly improve the clinical efficacy of colorectal cancer after chemotherapy.The mechanism may be related to the regulation of intestinal flora and immune response, protection of the intestinal barrier, improvement of immune function, and enhancement of disease resistance.