普罗帕酮与胺碘酮对心律失常患者的疗效对比

Comparison of Propafenone and Amiodarone in the Treatment of Arrhythmia

目的比较普罗帕酮与胺碘酮治疗心律失常患者的临床效果。方法将2017年9月至2018年9月到我院治疗的92例心律失常患者随机分为观察组与对照组,每组46例,对照组用药普罗帕酮,观察组用药胺碘酮,比较不同用药之后的治疗有效率、SDNN、SDNN_(Index)、rMSSD指标、室性早搏数、室性心动过速发作次数、用药不良反应发生率等。结果①观察组(44例,占95.65%)治疗以后的治疗有效率明显比对照组(38例,占82.61%)患者更高,数据有统计学差异(P<0.05)。②治疗前,两组患者的SDNN、SDNN_(Index)、rMSSD相关指标没有统计学差异(P>0.05),治疗之后,两组患者的SDNN、SDNN_(Index)、rMSSD指标均得到改善,但观察组的改善效果明显优于对照组,数据有统计学差异(P<0.05)。③治疗前,两组患者的室性早搏数与室性心动过速发作次数没有统计学差异(P>0.05),治疗之后,两组患者的室性早搏数与室性心动过速发作次数均得到改善,但观察组的改善效果明显优于对照组,数据有统计学差异(P<0.05)。④观察组(4例,占8.70%)患者治疗之后的不良反应发生率和对照组(3例,占6.52%)患者相比无明显差异,数据无统计学差异(P>0.05)。结论相比普罗帕酮,胺碘酮治疗心律失常患者的效果更明显,利于改善患者临床症状,减少患者室性心动过速发作次数,用药安全。

Objective To compare the clinical effect of propafenone and amiodarone in the treatment of arrhythmia.Methods All 92 patients with arrhythmia who came to our hospital for treatment from September 2017 to September 2018 were randomly divided into observation group and control group,each with 46 cases.The control group was treated with propafenone and the observation group was treated with amiodarone.The effective rate of treatment after different medications,SDNN,SDNN_(Index),rMSSD indicators,ventricular premature beats,number of ventricular tachycardia episodes,incidence of adverse drug reactions,etc.Results(1)The effective rate of treatment after treatment in the observation group(44 cases,accounting for 95.65%)was significantly higher than that of the control group(38 cases,accounting for 82.61%),and the data was statistically different(P<0.05).(2)Before treatment,there was no statistical difference in SDNN,SDNN_(Index),rMSSD related indicators between the two groups of patients(P>0.05).After treatment,the SDNN,SDNN_(Index),and rMSSD indicators of the two groups were improved,but the improvement effect of the observation group was significantly better than that of the observation group.In the control group,the data was statistically different(P<0.05).(3)Before treatment,the number of ventricular premature beats and the number of ventricular tachycardia episodes were not statistically different between the two groups(P>0.05).After treatment,the two the number of ventricular premature beats and the number of ventricular tachycardia episodes of the patients in the group were improved,but the improvement effect of the observation group was significantly better than that of the control group,and the data was statistically different(P<0.05).(4)the observation group(4 cases,8.7%)there was no significant difference in the incidence of adverse reactions between patients after treatment and the control group(3 cases,accounting for 6.52%),and the data was not statistically different(P>0.05).Conclusion Compared with propafenone,amiodarone is more effective in the treatment of arrhythmia.It can improve the clinical symptoms of patients,reduce the frequency of ventricular tachycardia attack,and it is safe.