清心滋肾汤调节神经-内分泌治疗绝经综合征心肾不交证的疗效观察

Observation on the therapeutic effect of Qingxin Zishen Decoction on regulating nerve-endocrine in the treatment of menopausal syndrome with heart-kidney incompatibility

目的探讨清心滋肾汤调节神经-内分泌治疗绝经综合征(MPS)心肾不交证的临床疗效。方法选取88例MPS心肾不交证患者,按照随机数字表法分为治疗组与对照组,每组44例。对照组给予雌二醇/醋酸炔诺翻片治疗,治疗组在对照组基础上内服清心滋肾汤治疗。比较两组治疗前后Kupperman指数(KI)、围绝经期生存质量量表(MENQOL)评分、血清雌二醇(E)、卵泡刺激素(FSH)、促黄体生成素(LH)、5-羟色胺(5-HT)及去甲肾上腺素(NE)水平。结果治疗前,两组KI、MENQOL评分比较,差异无统计学意义(P>0.05);治疗后,两组KI、MENQOL评分均明显低于治疗前,且治疗组KI、MENQOL评分分别为(8.47±1.01)、(15.04±1.95)分,均明显低于对照组的(13.44±1.73)、(18.83±2.94)分,差异具有统计学意义(P<0.05)。治疗前,两组E2、FSH、LH水平比较,差异无统计学意义(P>0.05);治疗后,两组血清FSH、LH水平均显著下降,Ez水平明显增加,且治疗组E,水平高于对照组,FSH、LH水平均低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组血清5-HT、NE水平比较,差异无统计学意义(P>0.05);治疗后,两组血清5-HT、NE水平明显增加,且治疗组明显高于对照组,差异具有统计学意义(P<0.05)。结论在西医常规干预基础上,清心滋肾汤治疗MPS心肾不交证可改善患者临床症状,提高生活质量,调节内分泌激素和神经递质,值得临床推广与应用。

Objective To explore the effect of Qingxin Zishen decoction on regulating nerve-endocrine therapy in treating menopausal syndrome(MPS)with heart-kidney incompatibility.Methods 88 patients with cardiac and renal insufficiency of MPS were selected and divided into treatment group and control group according to random number table method,with 44 cases in each group.The control group was given estradiol/norethinne acetate tablets,and the treatment group was given Qingxin Zishen decoction on the basis of the control group.Kupperman index(KI),perimenopausal quality of Life Scale(MENQOL)score,serum levels of estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),5-hydroxytryptophan(5-HT)and norepinephrine(NE)were compared between 2 groups before and after treatment.Results Before treatment,there was no significant difference in KI and MENQOL scores between the two groups(P>0.05).After treatment,KI and MENQOL scores in the two groups were significantly lower than before,and KI and MENQOL scores in the treatment group were(8.47±1.01)and(15.04±1.95)points,respectively,which were significantly lower than those in the control group(13.44±1.73)and(18.83±2.94)points.The difference was statistically significant(P<0.05).Before treatment,there were no significant differences in E2,FSH and LH levels between the two groups(P>0.05).After treatment,serum FSH and LH levels in both groups were significantly decreased,while E2 level was significantly increased,and E2 level in the treatment group was higher than that in the control group,while FSH and LH levels were lower than that in the control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in serum 5-HT and NE levels between 2 groups(P>0.05).After treatment,serum 5-HT and NE levels in the two groups were significantly increased,and the levels in the treatment group were significantly higher than those in the control group,with statistical significance(P<0.05).Conclusion On the basis of conventional intervention in Western medicine,Qingxin Zishen decoction can improve clinical symptoms,improve quality of life,regulate endocrine hormones and neurotransmitters,which is worthy of clinical promotion and application.