期刊文献+

血管免疫母细胞性T细胞淋巴瘤的临床病理特征研究

下载PDF
导出
摘要 目的:分析血管免疫母细胞性T细胞淋巴瘤(AITL)的临床病理特征,为临床上诊断该病提供依据。方法:选择南京市浦口区中心医院收治的11例AITL患者作为研究对象。对这些患者的临床病理资料进行回顾性分析,总结AITL的临床病理特征。结果:对11例AITL患者送检的淋巴结标本进行肉眼检查的结果显示,这些淋巴结均存在不同程度的增大,其长径为1~4.7 cm,均可见包膜存在。镜下检查可见个别淋巴结残存萎缩的生发中心,但大部分淋巴结的结构完全消失;部分标本存在明显的淋巴结包膜浸润现象,可见典型的肿瘤细胞弥漫浸润(为较小的淋巴样细胞弥漫浸润)、核膜存在和颜色较淡的胞质,肿胀的内皮细胞呈分枝状;背景可见反应性的小淋巴细胞、浆细胞、嗜酸性粒细胞、组织细胞增生,且滤泡树突状细胞增生明显,分布为网状。11例患者送检的淋巴结标本经免疫组化检查均可见CD3呈弥漫性表达,CD10、Bcl-6和CXCL13呈不同程度的表达,CD8和CD4呈混合性表达。结论:AITL的临床病理特征主要是淋巴结存在不同程度的增大、淋巴结包膜存在,镜检可见大部分淋巴结的结构完全消失及典型的肿瘤细胞弥漫浸润,进行免疫组化检查可见CD3呈弥漫性表达、CD10、Bcl-6和CXCL13呈不同程度的表达。
出处 《当代医药论丛》 2022年第1期23-26,共4页
  • 相关文献

参考文献5

二级参考文献33

  • 1Jaffe ES, Harris NL, Stein H, et al. World Health Orgalnization classification of tumors. Pathology and genetics of tumors of haematopoietic and lymphoid tissues [ M ]. Lyon : IARC Press, 2001.110 - 253.
  • 2Swerdlow SH, Campo E, Harris NL, et al. Health WHO classification of tumors of haematopoietic and lymphoid tissues [M]. Lyon: IARC Press, 2008. 168 -334.
  • 3Zelenetz AD, Advani RH, Byrd JC, et al. NCCN clinical practice guidelines in ontology^TM. Non-Hodgkin's Lymphomas. v. 2 2008. www. neen. org.
  • 4de Leval L, Rickman DS, Thielen C, et al. The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) ceils. Blood, 2007,109 : 4954-4963.
  • 5Dupuis J, Boye K, Martin N, et al. Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL) : a new diagnostic marker providing evidence that AITL derives from follicular helper T cells. Am J Surg Pathol, 2006,30:490-494.
  • 6Dorfman DM, Brown JA, Shahsafaei A. Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol, 2006, 30:802-810.
  • 7Tan BT, Warnke RA, Arber DA. The frequency of B- and T-cell gene rearrangements and Epstein-Barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations. J Mol Diagn, 2006, 8:466-475.
  • 8Kyriakou C, Canals C, Goldstone A, et al. High-dose therapy and autologous stem-cell transplantation in angioimmunoblastie lymphoma: complete remission at transplantation is the major determinant of Outeome-Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol, 2008, 26:218-224.
  • 9Advani R, Horwitz S, Zelenetz A, et al. Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine. Leuk Lymphoma, 2007, 48:521-525.
  • 10Dogan A, Ngu LS, Ng SH, et al. Pathology and clinical features of angioimmunoblastic T-cell lymphoma after successful treatement with thalidomide. Leukemia, 2005,19 : 873-875.

共引文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部