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血管免疫母细胞性T细胞淋巴瘤的临床病理特征研究

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摘要 目的:分析血管免疫母细胞性T细胞淋巴瘤(AITL)的临床病理特征,为临床上诊断该病提供依据。方法:选择南京市浦口区中心医院收治的11例AITL患者作为研究对象。对这些患者的临床病理资料进行回顾性分析,总结AITL的临床病理特征。结果:对11例AITL患者送检的淋巴结标本进行肉眼检查的结果显示,这些淋巴结均存在不同程度的增大,其长径为1~4.7 cm,均可见包膜存在。镜下检查可见个别淋巴结残存萎缩的生发中心,但大部分淋巴结的结构完全消失;部分标本存在明显的淋巴结包膜浸润现象,可见典型的肿瘤细胞弥漫浸润(为较小的淋巴样细胞弥漫浸润)、核膜存在和颜色较淡的胞质,肿胀的内皮细胞呈分枝状;背景可见反应性的小淋巴细胞、浆细胞、嗜酸性粒细胞、组织细胞增生,且滤泡树突状细胞增生明显,分布为网状。11例患者送检的淋巴结标本经免疫组化检查均可见CD3呈弥漫性表达,CD10、Bcl-6和CXCL13呈不同程度的表达,CD8和CD4呈混合性表达。结论:AITL的临床病理特征主要是淋巴结存在不同程度的增大、淋巴结包膜存在,镜检可见大部分淋巴结的结构完全消失及典型的肿瘤细胞弥漫浸润,进行免疫组化检查可见CD3呈弥漫性表达、CD10、Bcl-6和CXCL13呈不同程度的表达。
出处 《当代医药论丛》 2022年第1期23-26,共4页
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