miR-1246和NFIB在肝癌组织中的表达及其与肝癌预后的关系

The expression of miR-1246 and NFIB in liver cancer tissues and their relationship with prognosis

目的:探讨微小核糖核酸-1246(miR-1246)和核因子I/B(NFIB)在肝癌组织中的表达水平,分析二者与预后的关系。方法:纳入我院2017年3月至2019年3月收治的肝癌患者160例,均获得癌组织及癌旁组织,检测癌组织、癌旁组织中miR-1246和NFIB的表达情况,分析二者与临床病理特征的关系。根据患者24个月的累积生存情况分成生存组、死亡组,比较两组癌组织中miR-1246、NFIB表达情况,经Cox多元回归模型分析预后的危险因素。结果:肝癌组织中miR-1246表达量高于癌旁组织,NFIB高表达率高于癌旁组织(P<0.05)。miR-1246、NFIB高表达组临床分期Ⅲ期、肿瘤直径≥5 cm、多发性肿瘤比例高于低表达组,且NFIB高表达组ALT>40 U·L^(-1)比例高于低表达组(P<0.05)。生存组miR-1246、NFIB高表达率低于死亡组(P<0.05)。Cox多元回归分析显示临床分期Ⅲ期、肿瘤直径≥5 cm、多发性肿瘤以及miR-1246、NFIB高表达是预后的危险因素(P<0.05)。结论:肝癌组织中miR-1246表达量以及NFIB高表达率较癌旁组织增高,二者对患者预后影响较大,有望成为评估预后的指标。

Objective:To explore the expression levels of microribonucleic acid-1246(miR-1246)and nuclear factor I/B(NFIB)in liver cancer tissues,and analyze the relationship between the two and the prognosis.Methods:160 cases of liver cancer patients admitted to our hospital from March 2017 to March 2019 were included,and all cancer tissues and paracancerous tissues were obtained.The expression of miR-1246 and NFIB in the cancer tissues and paracancerous tissues were detected,and the relationship between them and clinicopathological features was analyzed.The patients were divided into survival group and death group according to their survival condition 24 months of involvement.The expressions of miR-1246 and NFIB in cancer tissues of the two groups were compared,and the risk factors of prognosis were analyzed by Cox multiple regression model.Results:The expression of miR-1246 in liver cancer tissue was higher than that in adjacent tissues,and the high expression rate of NFIB was higher than that in adjacent tissues(P<0.05).The clinical stageⅢ,tumor diameter≥5 cm,the proportion of multiple tumors in miR-1246 and NFIB high expression group were higher than those in low expression group,and the proportion of ALT>40 U·L^(-1) in NFIB high expression group was higher than that in low expression group(P<0.05).The high expression rate of miR-1246 and NFIB in the survival group was lower than that in the death group(P<0.05).Cox multiple regression analysis indicated that clinical stageⅢ,tumor diameter≥5 cm,multiple tumors,and high expression of miR-1246 and NFIB were prognostic risk factors(P<0.05).Conclusion:The expression of miR-1246 and the high expression rate of NFIB in liver cancer tissues are higher than those in adjacent tissues.Both have a greater impact on the prognosis of patients and are expected to be indicators for evaluating prognosis.