四君子汤及其加味方防治肿瘤的机制研究进展

Research Progress on Mechanism of Sijunzi Decoction And Its Modified Formula In Prevention and Treatment of Tumor

四君子汤是健脾益气经典方,其在抗肿瘤方面发挥重要作用。该文总结了四君子汤及加味方在防治癌前病变,抑制肿瘤细胞增殖、诱导细胞凋亡、抑制肿瘤血管生成、抑制肿瘤细胞侵袭转移、改善肿瘤恶病质、调节肿瘤微环境、调节机体免疫功能等方面的机制研究,为其抗肿瘤的深入研究以及在临床上的合理应用提供理论依据。

Sijunzi Decoction is the classic formula to reinforce Spleen-Qi,which plays an important role in anti-tumor.This study summarized the mechanism of Sijunzi Decoction and its modified formula in preventing and treating precancerous lesions,inhibiting tumor cell proliferation,inducing apoptosis,inhibiting tumor angiogenesis,inhibiting tumor cell invasion and metastasis,improving tumor cachexia,regulating tumor microenvironment and regulating immune function to provide a theoretical basis for the in-depth study of its antitumor and its rational clinical application.