电刺激控制释放地塞米松导电生物膜的制备与性能

Preparation and Properties of Conductive Biofilm for Controlled Release of Dexamethasone by Electrical Stimulation

为了降低神经电极植入机体产生的炎症反应,构建了一种纳米微结构复合电极。先将多壁碳纳米管(MWCNTs)和地塞米松磷酸钠(Dex)超声混匀后滴涂到电极上,再通过电化学聚合法将一层聚吡咯/聚苯乙烯磺酸钠(PPy/PSS)沉积到MWCNTs覆盖的电极表面,获得一种功能化导电生物膜MWCNTs/Dex@PPy/PSS。采用场发射扫描电镜和傅里叶变换红外光谱对导电生物膜的形貌和成分进行表征,并采用循环伏安法和阻抗扫描对修饰电极的电化学性能进行分析。结果表明,与PPy/Dex导电生物膜相比,所制备的MWCNTs/Dex@PPy/PSS生物膜表现出三维结构表面形貌和更高的电荷存储容量、更低的阻抗及更高的药物释放能力。

In order to reduce the inflammatory response caused by the implantation of nerve electrodes into body,a nano-microstructure composite electrode was constructed.Firstly,multi-walled carbon nanotubes(MWCNTs)and dexamethasone sodium phosphate(Dex)were mixed and dropped onto the electrode after ultrasonic mixing,and then polypyrrole/sodium polystyrene sulfonate(PPy/PSS)was deposited on the electrode surface covered with MWCNTs by electrochemical polymerization,to obtain a functional conductive biofilm MWCNTs/Dex@PPy/PSS.FESEM and FT-IR were used to characterize the morphology and composition of conductive biofilms,and the electrochemical properties of the modified electrodes were analyzed by cyclic voltammetry(CV)and impedance scanning(EIS).The results show that compared with the PPy/Dex conductive biofilm,the prepared MWCNTs/Dex@PPy/PSS conductive biofilm shows a three-dimensional structure surface morphology,higher charge storage capacity,lower impedance,and higher drug release ability.