基于微生物视角的“皮-肺-肠”轴与过敏性疾病

The Relationship between“Skin-Lung-Gut”Axis and Allergic Diseases Based on the Microbiome Perspective

在《内经》“肺合大肠,大肠者,皮其应”的中医肺藏象理论的基础上,“皮”“肺”“肠”三者在生理、病理的密切关系构成了环型体系,对于中药外治的理论研究、临床研究及实验研究具有指导意义。现代“皮-肺-肠”轴的提出主要从实体结构、免疫、内分泌、神经等方面探讨三者的联系。近年来,皮肤微生态受到越来越多的关注,笔者基于微生物的视角探讨“皮-肺-肠”轴在以特应性皮炎为起点的“特应性进程”过敏性疾病中的时空关联。基于“皮-肺-肠”轴的皮肤微生物调节为过敏性疾病的预防和治疗提供了新视角,也为中药外用制剂的机制研究提供了新思路。

On the basis of the theory"Lung combined with Gut,Gut connected to Skin"in Neijing,the"skin","lung"and"gut"in close relationship constitutes the physiology and pathology triangle,the three will influence each other in their respective disease system.This theory has guiding significance for the theoretical research,clinical research and experimental research of external Chinese medicine.The modern research of"skin-lung-gut"axis is proposed to discuss the relationship between the three in terms of physical structure,immunity,endocrine,and nerves.In recent years,the skin microecology has received more and more attention.Based on the perspective of microbiome,this article explores the temporal and spatial correlation of"skin","lung"and"gut"in the"atopic march"allergic diseases starting from atopic dermatitis.Regulation of skin microbiome based on"skin-lung-gut"axis provides not only a new perspective for the prevention and treatment of allergic diseases,but also new ideas for the mechanism research of external preparations of Chinese medicine.