1.5T MRI联合血浆miR-124对急性脑卒中患者的临床诊断价值

Clinical Diagnostic Value of 1.5T MRI Combined with Plasma miR-124 in Patients with Acute Stroke

目的探究1.5T MRI联合血浆miR-124对急性脑卒中患者的临床诊断价值。方法选取2018年3月至2019年7月我院神经内科诊治的85例疑似急性脑卒中患者进行研究。同期体检健康者40例作为健康组。患者均进行MRI检查,检查血浆小miRNA-124(miR-124)相对表达量,并对检测结果进行评价。结果miR-124诊断急性脑卒中总准确率为70.64%,miR-124诊断结果与脑CT的Kappa值为0.184(P<0.001);MRI诊断急性脑卒中总准确率为83.53%,MIR诊断结果与脑CT的Kappa值为0.478(P<0.001);两种方式联合诊断急性脑卒中总准确率为90.61%,两种方式联合诊断与脑CT的Kappa值为0.640(P<0.001);两者联合诊断急性脑卒中与脑CT的一致性优于单纯的MIR与miR-124。结论1.5T MRI联合血浆miR-124对急性脑卒中患者诊断准确率较高,优于单纯采用血浆miR-124和MRI检查。

Objective To explore the clinical diagnostic value of 1.5T MRI combined with plasma miR-124 in patients with acute stroke.Methods A total of 85 patients with suspected acute stroke diagnosed and treated in our neurology department from March 2018 to July 2019 were enrolled;In the meantime,40 healthy people were selected as the healthy group.All patients underwent MRI examination to check the relative expression of small miRNA-124(miR-124)in plasma.The test results were evaluated.Results The total accuracy rate of miR-124 in the diagnosis of acute stroke was 70.64%,and the Kappa value of the diagnosis results of miR-124 and brain CT was 0.184(P<0.001);the total accuracy rate of MRI diagnosis of acute stroke was 83.53%.The Kappa value of CT was 0.478(P<0.001);the total accuracy of the two methods in the diagnosis of acute stroke was 90.61%,and the Kappa value of the two methods combined with brain CT was 0.640(P<0.001).The agreement between the two methods in the diagnosis of acute stroke and brain CT was better than that of MIR and miR-124 alone.Conclusion The accuracy of 1.5T MRI combined with plasma miR-124 in patients with acute stroke is higher than that of plasma miR-124 and MRI alone.