雄激素受体在T1期三阴性乳腺癌组织中的表达及其临床意义

Expression and clinical significance of androgen receptor in T1 triple-negative breast cancer tissues

目的研究雄激素受体(AR)在T1期三阴性乳腺癌(TNBC)组织中的表达及其临床意义。方法收集2015年3月-2017年3月宣城市中心医院肿瘤科收治的87例T1期TNBC患者的癌组织和癌旁组织标本,采用免疫组化法检测癌组织和癌旁组织中AR的表达;采用单因素分析和多因素Logistic回归模型分析AR的表达与患者临床病理特征的关系;经Kaplan-Meier生存曲线分析T1期TNBC患者AR表达与预后生存期的关系。结果87例T1期TNBC患者中,AR阳性表达28例(32.18%),低于癌旁组织70例(80.45%)。AR在细胞核相关抗原Ki67(Ki-67)指数≥20%、组织学分级为G3、腋窝淋巴结转移患者中阳性表达率降低;其中,Ki-67指数、组织学分级是AR表达的独立影响因素(P<0.05)。截止至2020年3月31日,R阳性组总生存率为82.14%(23/28),高于AR阴性组59.32%(35/59)(P<0.05)。AR阳性组中位生存时间为49个月,大于AR阴性组中位生存时间39个月(P<0.05)。结论在T1期TNBC中存在AR的阳性表达,但阳性表达率较低。Ki-67指数、组织学分级是TNBC患者AR表达的独立影响因素。AR阳性表达预示着TNBC患者生存预后良好。

Objective To detect the expression of androgen receptor(AR)in T1 triple-negative breast cancer(TNBC)tissues and to explore its clinical significance.Methods Collected the cancer tissues and adjacent tissues of 87 T1 stage TNBC patients in the hospital from March 2015 to March 2017,and detected the expression of AR in the cancer tissues and the adjacent tissues by immunohistochemistry.Factor analysis and multivariate logistic regression model were used to analyze the relationship between AR expression and clinicopathological characteristics of patients.Kaplan-Meier survival curve was used to analyze the relationship between AR expression and prognostic survival in patients with T1 TNBC.Results Among the 87 T1 TNBC patients,28(32.18%)had AR positive expression,which was lower than 70(80.45%)of the adjacent tissues.The positive expression rate of AR decreased in patients with nuclear related antigen Ki67(Ki-67)index≥20%,histological grade G3,and metastatic axillary lymph nodes;Ki-67 index and histological grade were independent influencing factors of AR expression(P<0.05).As of March 31,2020,the total survival rate in the AR-positive group was 82.14%(23/28),which was higher than that in the AR-negative group 59.32%(35/59)(P<0.05).The median survival time of the AR-positive group was 49 months,which was more than that of the AR-negative group of 39 months(P<0.05).Conclusion There is a positive expression of AR in TNBC of T1 phase,but the positive expression rate is low.Ki-67 index and histological grade are independent factors for influencing AR expression in TNBC patients.In addition,AR positive expression could predict a good prognosis in patients with TNBC.