三维动脉自旋标记灌注成像显示学龄前孤独症儿童部分脑区血流下降

Three-dimensional arterial spin labeling perfusion imaging shows cerebral blood flow decline in some brain regions in preschool autistic children

目的探讨三维动脉自旋标记(three dimensional-arterial spin labeling,3D-ASL)灌注成像在学龄前孤独症儿童脑部的应用可行性。材料与方法选取2、3、4、5岁孤独症儿童各40名为研究组,选取2、3、4、5岁健康儿童各40名为对照组,所有儿童均行磁共振常规序列、3D-T1、3D-ASL序列扫描。通过软件后处理获得脑部各区脑血流量(cerebral blood flow,CBF)灌注值,比较分析相同年龄段孤独症儿童和健康儿童脑部各区血流灌注CBF值,找出各年龄段孤独症儿童脑部各区脑血流灌注CBF值特点。结果2岁组,孤独症儿童颞叶、海马、壳核等脑区CBF值低于健康儿童(P<0.05);3岁组,孤独症儿童额叶、颞叶、海马、壳核等脑区CBF值低于健康儿童(P<0.05);4岁组,孤独症儿童颞叶、额叶、丘脑、海马、壳核、尾状核等脑区CBF值低于健康儿童(P<0.05);5岁组,孤独症儿童颞叶、丘脑、海马、壳核、尾状核、黑质、红核等脑区CBF值低于健康儿童(P<0.05)。结论3D-ASL技术可以反映脑血流灌注情况,可以更加全面地反映孤独症儿童病理过程。

Objective:To explore the feasibility of three-dimensional arterial spin labeling(3D-ASL)perfusion imaging in the brain of children with preschool autism.Materials and Meythods:Each 40 autistic children aged 2,3,4,5 were selected,and 40 healthy children aged 2,3,4,5 were control groups,and all children underwent routine MR and 3D-T1,3D-ASL scans.The value of cerebral blood perfusion(CBF)was obtained by software posttreatment,compared the value of autistic children of the same age and healthy children,and found the characteristics of CBF in autistic children of all ages.Results:In the 2 years old group,the CBF values of temporal lobe,hippocampus and putamen in autistic children were lower than those in healthy children;in the 3 years old group,the CBF values of frontal lobe,temporal lobe,parietal lobe,hippocampus and putamen of autistic children were lower than those of healthy children;in the 4 years old group,the CBF values of temporal lobe,frontal lobe,parietal lobe,hippocampus,putamen and caudate nucleus in autistic children were lower than those in healthy children;in the 5 years old group,the CBF values of temporal lobe,parietal lobe,hippocampus,putamen and caudate nucleus in autistic children were lower than those in healthy children.Conclusions:3D-ASL technology can reflect cerebral blood flow perfusion and more comprehensively reflect the pathological process in children with autism.