基于体外受精-胚胎移植技术探讨郑惠芳补肾健脾法提高卵细胞质量经验

Exploration of Professor ZHENG Huifang’s Tonifying Kidney and Invigorating Spleen in Improving Oocyte Quality Based on IVF-ET Technique

不孕症的发病率逐年提高,体外受精-胚胎移植(IVF-ET)技术为有效治疗措施,但成功率仍有待提高。究其原因,卵母细胞质量差是体外受精(IVF)仍不能成功怀孕的原因之一。郑惠芳教授认为,脾肾虚损是疾病发生发展的根源,在此基础上可化痰、生瘀而成标病。郑老辨治不孕症,非常重视五脏功能的调理,强调温补肾脾的同时要注重调肝养肝,提出“基于阴阳互根、治肾当用温补;健脾补行并举、旁涉心肾两脏;调肝疏养并施、柔顺缓急为要”等观点,处方用药具有温补特色。总结郑老的理论观点与遣方用药思路,以期为临床改善不孕症患者卵细胞质量提供理论基础和治疗思路。

The incidence rate of infertility has been increasing year by year.In vitro fertilization embryo transfer(IVF-ET)technology is an effective treatment measure,however,the success rate is still to be improved.The poor quality of oocytes is one of the reasons for the infertility.Professor ZHENG Huifang believes that the deficiency of the spleen and kidney is the root cause of the occurrence and development of the disease and the deficiency can further dissipate phlegm and generate blood stasis.In the treatment of infertility,Master ZHENG attaches great importance to the regulation of the functions of the five internal organs,emphasizes that while warming and tonifying the kidney and spleen,attention should be paid to regulate and nourish the liver,and she puts forward the views that“warming and tonifying the kidney should be based on the interdependence between yin and yang;strengthening the spleen should be combined with tonifying the heart and kidney;regulating and nourishing the liver should be combined simultaneously and softening and slowing is the key”.The prescription shows the characteristics of warming and tonifying.This thesis intends to summarize Master ZHENG’s theoretical views and medication ideas,in order to provide theoretical basis and treatment ideas for clinical improvement of oocyte quality in patients with infertility.