通瘀明目推拿法治疗2型糖尿病视网膜病变非增殖期疗效观察及对血清NO、ET水平的影响

Effect of“Tongyu Mingmu”Tuina on the expressions of NO and ET in patients with type 2 diabetic retinopathy(non proliferative stage)

目的:研究通瘀明目推拿法对2型糖尿病非增殖期视网膜病变(DR)的临床效果,以及对血清一氧化氮(NO)、内皮素(ET)水平的影响。方法:纳入96例DR非增殖期病例,随机分为对照组与观察组各48例。对照组采用常规西药治疗,观察组在对照组常规西药治疗基础上给予通瘀明目推拿法治疗,均连续治疗4周。对综合疗效、治疗前后视网膜病变状况、视敏度、视力状况与血清NO、ET水平进行比较分析。结果:总体疗效比较观察组优于对照组(P<0.05);视网膜病变分期、视敏度与视力水平方面,治疗后观察组改善较对照组更明显(P<0.05);血清NO与ET水平,治疗后观察组均较对照组改善明显(P<0.05)。结论:通瘀明目推拿法联合羟苯磺酸钙分散片治疗2型糖尿病视网膜病变非增殖期可以提高患者视力水平、视敏度,改善视网膜病变分期,提高血清NO水平,降低ET水平,疗效优于单纯内服羟苯磺酸钙分散片。

Objective:To explore the clinical effect of“Tongyu Mingmu”Tuina in the treatment of type 2 diabetic retinopathy(non proliferative stage)and its effect on the level of serum NO and ET.Methods:A total of 96 patients with type 2 diabetic retinopathy(non proliferative stage)were randomly divided into control group and observation group.The control group was treated with conventional western medicine,and the observation group was treated with Tongyu Mingmu Tuina on the basis of conventional western medicine in the control group.All patients were treated for 4 weeks.The therapeutic effect,the Vision level,the visual acuity,degree of retinopathy and serum NO and ET levels were observed and compared between the two groups.Results:the overall curative effect of the observation group was better than that of the control group(P<0.05);The improvement of retinopathy stage,visual acuity and visual acuity in the observation group was more obvious than that in the control group(P<0.05);The levels of serum NO and ET in the observation group were significantly better than those in the control group after treatment(P<0.05).Conclusions:Tongyu Mingmu Tuina combined with calcium dobesilate dispersible tablets can improve the visual acuity and visual acuity of patients with type 2 diabetic retinopathy,improve the stage of retinopathy,improve the level of serum NO and reduce the level of ET.