摘要
目的:系统评价半夏泻心汤(BXD)联合中药灌肠治疗溃疡性结肠炎(UC)的临床疗效及安全性。方法:按Cochrane系统评价方法,检索万方数据知识服务平台(WF)、中国知网(CNKI)、维普期刊资源整合服务平台(VIP)、Pubmed及Web of Science数据库,查找采用BXD联合中药灌肠治疗UC的随机对照试验文献。通过RevMan 5.4软件对符合纳入标准的研究进行Meta分析。结果:共15项研究符合纳入标准,Meta分析提示,较常规西医治疗方法,BXD联合中药灌肠治疗UC可显著降低中医症状评分(SMD=-1.97,95%CI[-2.61,-1.33]),提高总有效率(RR=1.38,95%CI[1.30,1.46]),降低不良反应发生率(RR=0.25,95%CI[0.14,0.45])。结论:BXD联合中药灌肠治疗UC疗效确切,可明显改善患者便血、腹痛等症状,降低复发率及不良反应发生率。
Objective:To systematically evaluate the clinical efficacy and safety of Banxia Xiexin Decoction(半夏泻心汤)combined with Chinese herbal enema in treating ulcerative colitis(UC).Methods:Randomized controlled trials of Banxia Xiexin Decoction combined with Chinese herbal enema in treating UC were retrieved from the Wanfang Database knowledge Service Platform(WF),China National Knowledge Infrastructure(CNKI),Weipu Journal Resource Integration Service Platform(VIP),Pubmed and Web of Science by following the Cochrane system evaluation method.Meta-analysis was performed on the studies that met the inclusion criteria through RevMan 5.4 software.Results:Total 15 studies met the inclusion criteria.Meta analysis suggested that compared with conventional western medicine treatment,Banxia Xiexin Decoction combined with Chinese herbal enema treatment of UC could significantly reduce the symptom score of traditional Chinese medicine(SMD=-1.97,95%CI[-2.61,-1.33]),increase the total effective rate(RR=1.38,95%CI[1.30,1.46]);reduce the incidence of adverse reactions(RR=0.25,95%CI[0.14,0.45]).Conclusions:Banxia Xiexin Decoction combined with Chinese herbal enema has a definite effect on UC.It can not only significantly improve the symptoms of hematochezia and abdominal pain,but also reduce the recurrence rate and the incidence of adverse reactions.
作者
张梁坤
陈健
谷文超
黄海量
刘西健
韩涛
ZHANG Liangkun;CHEN Jian;GU Wenchao;HUANG Hailiang;LIU Xijian;HAN Tao(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Linqu ZHANG Xinsheng Chinese Medicine Clinic(Xinsheng Tang),Linqu 262600,China)
出处
《山东中医药大学学报》
2022年第1期64-71,共8页
Journal of Shandong University of Traditional Chinese Medicine
基金
全国名老中医药专家刘持年传承工作室建设项目(批文号:国中医药人教发〔2014〕20号)
2020年度山东省中医药科技面上项目(编号:2020M096)
2020年齐鲁卫生与健康领军人才培育工程(批文号:鲁卫人才字〔20204〕3号)
山东中医药大学首批科研创新优秀团队项目(编号:220316)。
关键词
半夏泻心汤
中药灌肠
溃疡性结肠炎
中医症状评分
临床有效率
不良反应
META分析
Banxia Xiexin Decoction
Chinese herbal enema
ulcerative colitis
the symptom score of traditional Chinese medicine
clinical effective rate
adverse reaction
Meta analysis