胶质母细胞瘤lncRNA-ROR的表达及其临床意义

Expression of lncRNA-ROR in glioblastoma tissues and its clinical meanings

目的探讨长链非编码RNA重编程调节因子(lncRNA-ROR)在胶质母细胞瘤(GBM)中的表达情况及其与病人预后的关系。方法选取2015年6月~2019年6月手术切除的GBM组织145例,取同期颅脑损伤内减压术切除非肿瘤脑组织56例为对照,采用qRT-PCR法检测lncRNA-ROR的相对表达量,根据lncRNA-ROR平均表达水平分为高表达和低表达。术后随访24个月,记录无进展生存期和总生存期。结果GBM组织lncRNA-ROR表达水平明显低于对照组(P<0.05)。多因素Cox回归分析显示lncRNA-ROR低表达是GBM生存预后不良的独立危险因素(P<0.05)。生存曲线分析显示,lncRNA-ROR高表达组2年累积无进展生存率(40.12%)与2年累积总生存率(48.56%)明显高于低表达组(分别为16.25%、19.85%;P<0.05)。结论GBM组织lncRNA-ROR呈低表达,与病人不良生存预后密切相关。这提示检测lncRNA-ROR对GBM病人预后具有一定评估价值。

Objective To investigate the expression of long chain noncoding RNA reprogramming regulator(lncRNA-ROR)in glioblastoma(GBM)tissues and its clinical meanings.Methods The expression levels lncRNA-ROR were detected using qRT-PCR in GBM tissues obtained from 145 GBM patients who underwent microsurgery and in non-tumor cerebral tissues obtained from 56 patients with trauatic brain injury who underwent decompression from June 2015 to June 2019.GBM patients were divided into high-expression and low-expression groups according to the average expression level of lncRNA-ROR.The patients with GBM were followed up for 24 months,and the progression-free survival(PFS)and overall survival(OS)were recorded.Results The expression level of lncRNA-ROR in GBM tissues was significantly lower than that in the control group(P<0.05).Multivariate Cox regression analysis showed that low expression of lncRNA-ROR was an independent risk factor for poor survival prognosis of GBM patients(P<0.05).Survival curve analysis showed that the 2-year cumulative PFS rate(40.12%)and 2-year cumulative OS rate(48.56%)of the lncRNA-ROR high-expression group were significantly higher than those(16.25%and 19.85%,respectively)of the low expression group(P<0.05).Conclusions The expression of lncRNA-ROR is low in GBM tissues,which is closely related to the poor survival prognosis of GBM patients.This suggests that the detection of lncRNA-ROR has a certain value in the prognosis evaluation of GBM patients.