NLRP3炎性小体在术后认知功能障碍中的研究进展

Research on NLRP3 inflammasome in postoperative cognitive dysfunction

术后认知功能障碍(POCD)是指术后发生的中枢神经系统并发症,主要表现为学习记忆能力下降、社交能力及认知能力障碍等。POCD的发生常与患者年龄和麻醉药物的使用等因素有关。近年来神经炎症在POCD发病机理中的作用受到了学者们的广泛关注,其中核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体的激活在中枢炎症反应中发挥关键作用。本文就NLRP3炎性小体在POCD中的研究进展作一综述。

Post-operative cognitive dysfunction(POCD)refers to the complications of central nervous system after operation,mainly including the decline of learning and memory ability,social ability and cognitive impairment.POCD is often related to the age of patients and the use of narcotic drugs.In recent years,the role of neuroinflammation in the pathogenesis of POCD has been widely concerned by scholars,in which the activation of nucleoside binding oligomerization domain like receptor protein 3(NLRP3)inflammatory bodies play a key role in the central inflammatory response.This paper reviews the research progress of NLRP3 in POCD.