多烯磷脂酰胆碱联合谷胱甘肽治疗妊娠期肝内胆汁淤积症的效果研究

Effect of polyene phosphatidylcholine combined with glutathione on intrah epatic cholestasis during pregnancy

目的:研究为妊娠期肝内胆汁淤积症患者采用多烯磷脂酰胆碱联合谷胱甘肽进行治疗的临床疗效。方法:将2020年1月至2021年6月期间在某院接受治疗的60例妊娠期肝内胆汁淤积症患者作为研究对象。采用随机数表法将其分为对照组(n=30)和观察组(n=30)。为对照组患者采用多烯磷脂酰胆碱进行治疗,为观察组患者采用多烯磷脂酰胆碱联合谷胱甘肽进行治疗,然后比较两组患者治疗的总有效率和治疗前后其血清总胆汁酸(TBA)、谷丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、磷脂转移蛋白(PLTP)、白介素-18(IL-18)的水平。结果:1)观察组患者治疗的总有效率〔93.3%(28/30)〕高于对照组患者治疗的总有效率〔70.0%(21/30)〕,P<0.05。2)治疗前,两组患者血清TBA、ALT、AST、TBIL的水平相比,P>0.05。治疗后,观察组患者血清TBA的水平〔(8.01±1.31)μmol/L〕、血清ALT的水平〔(21.62±7.40)U/L〕、血清AST的水平〔(22.67±8.28)U/L〕、血清TBIL的水平〔(7.81±2.21)U/L〕均低于对照组患者,P<0.05。3)治疗前,两组患者血清PLTP、IL-18的水平相比,P>0.05。治疗后,观察组患者血清PLTP的水平〔(3.12±0.29)pg/mL〕、血清IL-18的水平〔(57.86±5.94)ng/mL〕均低于对照组患者,P<0.05。结论:用多烯磷脂酰胆碱联合谷胱甘肽治疗妊娠期肝内胆汁淤积症的效果显著,可有效地改善患者的肝功能。

Objective:To study the clinical efficacy of polyene phosphatidylcholine combined with glutathione in the treatment of intrahepatic cholestasis of pregnancy.Methods:Sixty patients with intrahepatic cholestasis of pregnancy who were treated in a hospital from January 2020 to June 2021 were enrolled as subjects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was treated with polyene phosphatidylcholine,and the observation group was treated with polyene phosphatidylcholine combined with glutathione.Then,the total effective rate and the serum levels of total bile acid(T BA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),phospholipid transfer protein(PLTP)and interleukin-18(IL-18)in 2 groups before and after treatment were compared.Results:1)The total effective rate in obs ervation group(93.3%(28/30))was higher than that in control group(70.0%(21/30)),P<0.05.2)Before treatment,the levels of s erum TBA,ALT,AST and TBIL in 2 groups were compared,P>0.05.After treatment,T he levels of serum TBA(8.01±1.31)μmol/L),serum ALT(21.62±7.40 U/L),serum AST(22.67±8.28 U/L)and serum TBIL(7.81±2.21 U/L)in observation group were lower than those in control group.(P<0.05).3)Before treatment,the levels of serum PLTP and IL-18 in 2 groups were compared,P>0.05.After treatment,the levels of serum PLTP and serum IL-18 in observation group were lower than those in control group(3.12±0.29 pg/mL),P<0.05.Conclusion:Polyene phosphatidylcholine combined with glutathione is effective in the treatment of intrahepatic cholestasis of pregnancy,and can effectively improve the liver function of patients.