摘要
由于肝细胞癌的发生与发展机理复杂,目前还未充分揭示。作为人体基因组中规模最大的转录因子家族,锌指蛋白现已证实在包括肝癌在内的许多癌症中起到了关键性作用,现将对探讨锌指蛋白的构成、类型,以及在肝细胞癌中的作用机制方面进行综述。
Due to its complicated mechanism,the occurrence and development of hepatocellular carcinoma have not been fully revealed yet.As the largest transcription factor family in the human genome,zinc finger proteins have been confirmed to play a key role in many cancers,including liver cancer.The mechanism of action is reviewed in this article.
作者
张恒
张成
廖伟然
何宇涛
章宇洋
杜斌
王琳
ZHANG Heng;ZHANG Cheng;LIAO Weiran;HE Yutao;ZHANG Yuyang;DU Bin;WANG Lin(The 2nd Ward of Hepatobiliary Surgery,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)
出处
《昆明医科大学学报》
CAS
2022年第1期144-149,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81660399)
昆明医科大学研究生创新基金资助项目(2021S205)。
关键词
锌指蛋白
肝癌
基因调控
转录因子
Zinc finger protein
Liver cancer
Gene regulation
Transcription factor
