柴胡疏肝散加减治疗小儿肠系膜淋巴结炎(气滞血瘀型)临床研究

A clinical efficacy study on modified Chaihu Shugan Powder in the treatment of infantile mesenteric lymphadenitis(pattern of qi stagnation and blood stasis)

目的探讨柴胡疏肝散加减内服治疗小儿肠系膜淋巴结炎(气滞血瘀型)的临床疗效。方法按照随机数表法将80例肠系膜淋巴结炎(气滞血瘀型)患儿分成对照组和观察组,各40例。对照组采用脉冲磁治疗仪治疗,观察组采用脉冲磁治疗仪联合中药内服治疗,2组均连续治疗2周。观察2组治疗后中医证候积分、淋巴结纵经、横径、纵经/横径值、临床总有效率及复发率情况。结果观察组中医证候积分、淋巴结纵经、横径及纵经/横径值均低于对照组(P<0.05);观察组总有效率为97.50%,高于对照组的85.00%(P<0.05);观察组随访6个月复发率为4.35%,低于对照组的26.67%(P<0.05);2组治疗过程中均未发生与治疗相关的不良反应事件。结论脉冲磁治疗仪结合中药内服能够有效治疗小儿肠系膜淋巴结炎(气滞血瘀型),在缓解患儿临床症状、改善淋巴结肿大及降低复发率方面比单纯脉冲磁治疗仪更具优势。

Objective To explore the clinical efficacy of modified Chaihu Shugan Powder in the treatment of infantile mesenteric lymphadenitis with the pattern of qi stagnation and blood stasis.Methods A total of 80 children with mesenteric lymphadenitis (the qi stagnation and blood stasis pattern) were randomly divided into a control group and an observation group,each with 40 cases.The control group was treated with pulsed magnetic therapy instruments,while the observation group was treated with Chaihu Shugan Powder on that basis,both for two weeks.The TCM syndrome scores,longitudinal and transverse diameters of lymph nodes and their ratios,total clinical effective rates and recurrence rates of the two groups were observed after treatment,and the treatment scheme safety of the two groups was evaluated.Results The TCM syndrome score,longitudinal and transverse diameter of lymph nodes and their ratio in the observation group were lower than those in the control group (P<0.05).The total effective rate of the observation group (97.50%) was higher than that of the control group (85.00%) (P<0.05).The recurrence rate in the observation group (4.35%) after the 6-month follow-up was lower than that in the control group (26.67%) (P<0.05).There were no treatment-related adverse events in the two groups.Conclusion The application of pulsed magnetic therapy instruments combined with Chaihu Shugan Powder can effectively treat infantile mesenteric lymphadenitis with the pattern of qi stagnation and blood stasis,which has more advantages than the only instrument application in alleviating clinical symptoms,improving lymphadenectasis and reducing recurrence rate,and has a higher clinical application value.