咽喉部鳞状细胞癌细胞系

A review of squamous cell lines originating from the nasopharynx,oropharynx,laryngopharynx and larynx

咽喉部鳞状细胞癌是头颈外科常见恶性肿瘤,头颈部解剖结构复杂,原发部位不同的鳞状细胞癌发病率、诊疗方案不同,其发生的分子机制也可能存在差异。因此,选择适合的咽喉部鳞状细胞癌细胞系对于研究者选择适合的临床前研究模型,以及更好地理解肿瘤发生发展机制具有重要意义。总结了鼻咽、口咽、喉咽、喉四个解剖部位的鳞状细胞癌细胞系,以望对研究者选择适当的细胞系作为研究对象提供参考。

Larynx squamous cell carcinoma is a common malignant tumor of the head and neck region.The head and neck have complicated anatomical structure,and squamous cell carcinomas with different primary sites have different incidences,strategies of diagnosis and therapy,and even molecular pathogeneses.Therefore,selecting the suitable squamous cell carcinoma cell lines is important for researchers to determine appropriate preclinical research models and to have a better understanding of the mechanisms of tumorigenesis and progression.To provide a reference for researchers,this study summarizes the currently available squamous cell carcinoma cell lines originating from the nasopharynx,oropharynx,laryngopharynx and larynx.