多索茶碱联合噻托溴铵治疗慢阻肺患者的临床效果分析

Analysis of the clinical effect of the combination of doxofylline and tiotropium bromide in patients with chronic obstructive pulmonary disease

目的分析多索茶碱联合噻托溴铵治疗慢性阻塞性肺疾病(慢阻肺)的临床效果。方法80例慢阻肺患者,按照入院先后时间分为常规组和实验组,每组40例。常规组患者采用多索茶碱治疗,实验组患者采用多索茶碱联合噻托溴铵治疗。比较两组患者治疗效果、不良反应发生情况及治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)、FEV1占预计值的百分比(FEV1%pred)]。结果实验组患者治疗总有效率为95.00%,高于常规组的75.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者FEV1、PEF、FEV1%pred均高于本组治疗前,且实验组患者FEV1(1.66±0.26)L、PEF(197.65±10.61)L/min、FEV1%pred(55.76±9.58)%高于常规组的(1.51±0.32)L、(190.28±10.43)L/min、(49.92±9.53)%,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论应用多索茶碱联合噻托溴铵治疗慢阻肺,可提高治疗效果,改善肺功能,同时可保证用药安全性,值得临床借鉴。

Objective To analyze the clinical effect of the combination of doxofylline and tiotropium bromide in patients with chronic obstructive pulmonary disease.Methods A total of 80 patients with chronic obstructive pulmonary disease were divided into conventional group and experimental group according to the order of admission,with 40 cases in each group.Patients in the conventional group were treated with doxofylline,and patients in the experimental group were treated with doxofylline in combination with tiotropium bromide.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions,and pulmonary function indexes[forced expiratory volume in 1st second(FEV1),peak expiratory flow rate(PEF),percentage of FEV1 to the predicted value(FEV1%pred)]before and after treatment.Results The total effective rate of treatment in the experimental group was 95.00%,which was higher than 75.00%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the FEV1,PEF,and FEV1%pred of the two groups were higher than those of this group before treatment,and the experimental group had higher FEV1(1.66±0.26)L,PEF(197.65±10.61)L/min,and FEV1%pred(55.76±9.58)%than(1.51±0.32)L,(190.28±10.43)L/min,and(49.92±9.53)%of the conventional group;all the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of doxofylline and tiotropium bromide can improve the efficiency of treatment and improve the pulmonary function,and ensure the safety of drug use,which is worthy of clinical reference.