别嘌呤醇治疗老年高尿酸血症的疗效研究

Study on the efficacy of allopurinol in the treatment of elderly patients with hyperuricemia

目的评估别嘌呤醇在老年高尿酸血症患者治疗中的应用效果。方法66例老年高尿酸血症患者,运用随机数字表法分为试验组和对照组,各33例。对照组患者给予基础治疗,试验组患者给予基础治疗联合别嘌呤醇治疗。对比两组患者治疗前后的血尿酸水平、内皮功能指标(内皮素-1、一氧化氮)及治疗效果。结果治疗后,试验组的血尿酸水平(354.43±16.85)μmol/L低于对照组的(401.02±20.34)μmol/L,差异有统计学意义(P<0.05)。治疗后,试验组的内皮素-1低于对照组,一氧化氮高于对照组,差异有统计学意义(P<0.05)。试验组治疗总有效率93.94%高于对照组的75.76%,差异有统计学意义(P<0.05)。结论别嘌呤醇在老年高尿酸血症患者的治疗中有着良好的应用效果,值得推广。

Objective To evaluate the practical effect of allopurinol in the treatment of elderly patients with hyperuricemia.Methods A total of 66 elderly patients with hyperuricemia were divided into experimental group and control group according to random numerical table,with 33 cases in each group.The control group was treated with basic therapy,and the experimental group was treated with allopurinol based on the basic therapy.Both groups were compared in terms of blood uric acid levels,endothelial function indexes(human endothelin-1,nitric oxide)before and after treatment,and therapeutic effects.Results After treatment,the blood uric acid level(354.43±16.85)μmol/L of the experimental group was lower than(401.02±20.34)μmol/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the human endothelin-1 in the experimental group was lower than that of the control group,and the nitric oxide was higher than that of the control group.All the differences were statistically significant(P<0.05).The total effective rate of treatment 93.94%in the experimental group was higher than 75.76%in the control group,and the difference was statistically significant(P<0.05).Conclusion Allopurinol has good effect on elderly patients with hyperuricemia,and it is worthy of promotion.