α_(1)-酸性糖蛋白基本特征及代谢调节作用的研究进展

The research progress on the basic characteristics and metabolic regulation of α_(1)-1-acid glycoprotein

代谢稳态是机体生存必需的基础性功能。α_(1)-酸性糖蛋白(AGP)是一种急性期蛋白,糖基化程度高达45%,具有高亲和力、低容量的特性。虽然AGP的生物学作用尚不完全清楚,但已经证明它可以调节免疫和代谢,并在携带药物转运,维持毛细血管屏障功能等方面发挥着重要作用。综述AGP的结构特征、生化特性,以及AGP的表达调控和代谢调节作用,提示其可能是代谢通路上的一个潜在关键因子,成为代谢性疾病的一个新的研究方向。

Metabolic homeostasis is a basic function necessary for the survival of the organism.α_(1)-acid glycoprotein(AGP)is an acute phase protein with a glycosylation degree of up to 45%.It has high affinity and low capacity.Although the biological role of AGP is not fully understood,it has been proven that it can regulate immunity and metabolism,and play an important role in transporting drugs and maintaining capillary barrier function.In this review,the structural characteristics,biochemical characteristics and the regulation of AGP expression were reviewed,with emphasis on the regulatory role of AGP in metabolism,suggesting that AGP may be a potential key factor in metabolic pathways,which provides a new research direction for metabolic diseases.