摘要
近10年来,针对微生物-肠道-脑轴(MGBA)在调控神经系统发育和功能方面的生理、病理学研究迅速展开;肠道菌群的失调可能通过肠道神经系统、微生物代谢物(如短链脂肪酸)、神经炎症和免疫介导的“屏障缺陷”推动多种神经系统疾病的发生和发展。该文就MGBA在阿尔茨海默病、帕金森病和创伤性脑损伤中的潜在致病机制进行综述,为临床干预和治疗神经系统疾病提供新的思路。未来研究将更加侧重于由动物模型向临床试验的转化,以及阐明MGBA特异性影响神经系统疾病的深层机制。
In the past ten years,the physiological and pathological research on the microbe-gut-brain axis(MGBA)in regulating the development and function of the nervous system has been rapidly launched.Gut microbiota dysbiosis might promote the occurrence and development of neurological diseases through the enteric nervous system,microbial metabolites such as short-chain fatty acids,neuroinflammation and immune-mediated"defective barrier".This paper reviews the potential pathogenesis of MGBA in Alzheimer′s disease(AD),Parkinson′s disease(PD)and traumatic brain injury(TBI)to provide the new ideas for clinical intervention and treatment of neurological diseases.Future studies will focus on the transition from animal models to clinical trials and clarify the deep mechanism of MGBA specific influence on neurological diseases.
作者
吴依凡(综述)
杜东霖
孙晓川(审校)
WU Yifan;DU Donglin;SUN Xiaochuan(Department of Neurosurgery,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《重庆医学》
CAS
2022年第1期143-146,153,共5页
Chongqing medicine
基金
国家自然科学基金项目(82071397)。
