皮肤胆固醇含量与冠状动脉病变严重程度的相关性研究

Association between skin cholesterol content and the severity of coronary artery disease

目的:利用皮肤胆固醇无创检测系统检测不同狭窄程度冠状动脉(冠脉)病变患者的皮肤胆固醇水平,探索皮肤胆固醇含量与冠脉狭窄程度的关系及其在冠心病风险筛查领域中的应用价值。方法:本研究为前瞻性研究,入选中国科学技术大学附属第一医院2020年5月-2021年1月拟诊冠心病的住院患者168例,所有纳入患者近1个月内均未服用任何他汀类及其他降脂药物,住院当天接受皮肤胆固醇含量检测,住院期间完成冠脉造影,通过定量冠脉造影系统(QCA)评估冠脉狭窄严重程度,根据患者的基本临床信息,计算患者的弗明汉评分,分析皮肤胆固醇含量与冠脉狭窄严重程度以及弗明汉评分之间的相关性。结果:皮肤胆固醇含量随着冠脉狭窄严重程度的增加而增加;弗明汉评分超过10%的人群皮肤胆固醇含量显著高于弗明汉评分低于10%的人群;总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平与皮肤胆固醇含量没有显著的相关性。结论:皮肤胆固醇含量与冠脉狭窄严重程度以及弗明汉评分呈正相关,提示皮肤胆固醇含量在冠心病风险筛查领域中的应用前景良好。

Objective:To explore the relationship between skin cholesterol content and the severity of coronary artery disease and its application in coronary heart disease screening.Methods:A total of 168 inpatients with suspected coronary heart disease diagnosed in the First Affiliated Hospital of the University of Science and Technology of China from May 2020 to January 2021 were enrolled in this prospective study.All the included patients did not take any statins or other lipid-lowering drugs in the past month,the skin cholesterol content was detected on the day of hospitalization,and the severity of coronary artery stenosis was assessed through the quantitative coronary angiography system(QCA).Framingham risk score was calculated based on the patients’basic and clinical information.The correlation between skin cholesterol content and severity of coronary artery stenosis and Framingham risk score was assessed.Results:The skin cholesterol content increased with the severity of coronary artery stenosis.The skin cholesterol content in people with Framingham score more than 10%was significantly higher than that in people with Framingham score less than 10%.There was no significant correlation between the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C)and skin cholesterol content.Conclusion:Skin cholesterol content is positively correlated with the severity of coronary artery stenosis and Framingham score,suggesting that the non-invasive skin cholesterol detection may potentially be used as a risk assessment tool for coronary heart disease screening.