东莞市茶山镇社区居民的血清尿酸/肌酐比值与代谢综合征的关联

Association between serum uric acid to creatinine ratio and metabolic syndrome based on community residents in Chashan town,Dongguan city

目的分析东莞市茶山镇社区居民血清尿酸/肌酐比值(SUA/Cr)与代谢综合征之间的关联。方法研究对象来自2018—2019年在东莞市茶山镇开展的“华南区域自然人群慢性病前瞻性队列研究”,采用方便抽样的方法共纳入11334名数据完整的研究对象。通过问卷调查、体格检查收集人口学特征、生活方式及健康状况等信息;同时采集调查对象的静脉血以检测血清尿酸、肌酐、血脂等水平。根据SUA/Cr水平的四分位数将研究对象分为Q1~Q4组,采用logistic回归模型分析SUA/Cr和代谢综合征及其各组分(腹型肥胖、高甘油三酯、高密度脂蛋白胆固醇降低、高血压、葡萄糖代谢异常)的关联。结果11334名研究对象年龄为(49.52±10.02)岁,男性占44.2%(5015/11334),代谢综合征的患病率为31.2%(3532/11334),SUA/Cr水平为5.17±1.53。Q1~Q4组的代谢综合征患病率分别为22.3%(631/2834)、26.5%(752/2833)、34.9%(988/2833)、41.0%(1161/2834)。调整相关混杂因素后,多因素logistic回归模型分析结果显示,与Q1组相比,Q2~Q4组代谢综合征患病风险均显著升高,OR(95%CI)值分别为1.41(1.23~1.60)、2.19(1.93~2.49)、3.01(2.65~3.42);且Q2~Q4组代谢综合征各组分患病风险均较高,P趋势<0.001。尿酸水平正常的研究对象SUA/Cr水平与代谢综合征显著正相关,患代谢综合征的风险随着SUA/Cr水平上升而升高,但在高尿酸血症患者中有相同趋势但不显著(P交互=0.008)。结论东莞市茶山镇社区居民SUA/Cr水平与代谢综合征的患病风险呈正向关联。

Objective To analyze the association between serum uric acid to creatinine ratio(SUA/Cr)and metabolic syndrome among community residents in Chashan town,Dongguan city.Methods Participants were from the prospective cohort study of chronic diseases in natural populations in South China conducted in Chashan town,Dongguan city from 2018 to 2019.A total of 11334 participants with complete data were included by using convenient sampling method.Demographic characteristics,lifestyle and health status were collected through questionnaire and physical examination.The venous blood of the subjects was collected to detect the levels of serum uric acid,creatinine and blood lipid.All participants were divided into four groups(Q1-Q4)according to the quartile of SUA/Cr level.The relationship between SUA/Cr and metabolic syndrome and its components(abdominal obesity,high triglyceride,low level of high density lipoprotein cholesterol,hypertension and abnormal glucose metabolism)were analyzed by using logistic regression model.Results The mean age of 11334 participants was(49.52±10.02)years.Male participants accounted for 44.2%(5015/11334).The prevalence of metabolic syndrome was 31.2%(3532/11334),and the level of SUA/Cr was 5.17±1.53.The prevalence of metabolic syndrome in group Q1-Q4 was 22.3%(631/2834),26.5%(752/2833),34.9%(988/2833)and 41.0%(1161/2834),respectively.After adjusting for relevant confounding factors,the result of logistic regression model showed that compared with group Q1,the risk of metabolic syndrome in group Q2-Q4 was significantly higher,with OR(95%CI)values about 1.41(1.23-1.60),2.19(1.93-2.49)and 3.01(2.65-3.42)respectively.The risk of each component of metabolic syndrome in group Q2-Q4 was higher(Ptrend<0.001).The SUA/Cr level of participants with normal uric acid level was significantly positively correlated with metabolic syndrome.The risk of metabolic syndrome increased with the increase of SUA/Cr level,but there was the same trend without significant differences in patients with hyperuricemia(Pinteraction=0.008).Conclusion There is a positive correlation between SUA/Cr level and the risk of metabolic syndrome among community residents in Chashan town,Dongguan city.