流感通用疫苗研发技术平台与研究进展

Research and development technology platform and research progress of universal influenza vaccine

接种疫苗是预防流感最有效措施。然而,由于流感病毒存在抗原漂移和/或抗原转换,常常使疫苗毒株与流行毒株不匹配,以至于目前流感疫苗提供的保护非常有限。随着疫苗新技术的快速发展,具有广泛保护性或通用的流感疫苗受到极大关注。能够有效诱导针对流感病毒保守表位的体液免疫和细胞免疫,提供针对流感病毒各种型或亚型的良好保护,安全有效,且具备快速生产平台,是新一代通用型流感疫苗研发的理想目标。本文就流感通用疫苗研发技术平台与最新研究进展进行综述。

Vaccination is the most effective measure to prevent influenza.However,due to the existence of antigen drift and/or antigen shift of influenza virus,the vaccine strains often do not match the epidemic strains,so that the protection provided by influenza vaccine is still limited.With the rapid development of new vaccine technology,a kind of influenza vaccine with extensive protection or universal has attracted great attention.It can effectively induce humoral and cellular immunity against the conserved epitopes of influenza virus,provide good protection against various types/subtypes of influenza virus,and has a rapid production platform,which is the ideal goal for the development of a new generation of universal influenza vaccine.This article reviews the latest research progress of influenza universal vaccine.