桂枝茯苓丸治疗卵巢癌作用机制研究进展

Mechanisms of Guizhi Fulingwan Against Ovarian Cancer:A Review

卵巢癌是妇科三大恶性肿瘤之一。卵巢癌早期症状隐匿,大多发现即为晚期,是最致命的妇科肿瘤之一,已成为妇科及肿瘤领域的热点研究问题。桂枝茯苓丸出自《金匮要略》,是中医经典复方,也是治疗妇人癥瘕病的名方,具有化瘀生新、缓消癥块之效。该文通过检索中国知网(CNKI),PubMed,万方(Wanfang Data),维普(VIP)等数据库,对桂枝茯苓丸治疗卵巢癌的研究进行整合与梳理,阐述桂枝茯苓丸治疗卵巢癌的作用机制,以期为进一步研究药理作用和临床运用及推广提供思路及参考。在临床中,桂枝茯苓丸具有控制肌瘤生长、纠正血清学指标、提高化疗敏感性、增强机体抗肿瘤免疫、减少术后复发率、提高患者的生存质量等作用。在实验研究中,桂枝茯苓丸能通过促进线粒体途径凋亡、增强肿瘤免疫、抑制血管因子、阻滞细胞周期及逆转多药耐药等多种药理作用,可改善动物及细胞模型的病理状态。桂枝茯苓丸通过多靶点、多途径等机制对卵巢癌起到一定的治疗作用,同时体现了中医药治疗卵巢癌的优势和价值。

Ovarian cancer(OC)is one of the three major gynecological malignancies.Due to its insidious onset at the early stage,most of OC patients are diagnosed at the advanced stage,making it become one of the most deadly gynecological tumors and thus a hot topic in the field of gynecology and oncology.Guizhi Fulingwan is a classic Chinese herbal compound derived from Synopsis of Golden Chamber(《金匮要略》)for the treatment of abdominal mass in women on account of its efficacy in resolving stasis,generating new blood,and eliminating mass.The articles concerning the treatment of OC with Guizhi Fulingwan were searched from such databases as China National Knowledge Infrastructure(CNKI),PubMed,Wanfang Data Knowledge Service Platform,and Chongqing Weipu Database for Chinese Technical Periodicals(VIP)and collated for expounding its action mechanisms,in order to provide ideas for further research on its pharmacological effects,clinical application,and promotion.Clinically,Guizhi Fulingwan has been proved to control the growth of myoma,correct serological indexes,enhance chemotherapy sensitivity and anti-tumor immunity,reduce postoperative recurrence rate,and improve the quality of life of patients.As revealed by experimental research,Guizhi Fulingwan alleviates the pathological state of animal and cell models by promoting mitochondrial apoptosis and tumor immunity,inhibiting vascular factors,inducing cell cycle arrest,and reversing multidrug resistance.Guizhi Fulingwan exerts a certain therapeutic effect on OC through multi-target and multi-channel mechanisms,reflecting the advantages of traditional Chinese medicine in treating OC.