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地诺孕素治疗子宫腺肌病的研究进展 被引量:17

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摘要 子宫腺肌病的临床表现主要为痛经、月经过多、子宫增大和不孕,是一种需要长期管理的慢性疾病,近来药物治疗越来越受到重视。地诺孕素是第4代人工合成孕激素,近年来在子宫内膜异位症的治疗方面取得了良好的效果,子宫腺肌病作为子宫内膜异位症同源疾病,地诺孕素对子宫腺肌病疼痛症状疗效显著,能够提高血红蛋白含量,维持基础雌激素水平,不引起低雌激素症状,可长期使用,治疗过程中常见可耐受的异常子宫出血,但临床应用仍需更多研究和探索。
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2021年第12期876-880,共5页 Chinese Journal of Obstetrics and Gynecology
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  • 1向阳.子宫动脉栓塞术治疗子宫肌瘤的相关问题[J].中国实用妇科与产科杂志,2008,24(1):28-30. 被引量:16
  • 2Sasagawa S, Shimizu Y, Kami H, et al. Dienogest is a selective progesterone receptor agonist in transaetivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile[J]. Steroids, 2008, 73(2):222-231.
  • 3Sasagawa S, Shimizu Y, Nagaoka T, et al. Dienogest, a selective progestin, reduces plasma estradiol level through induction of apoptosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys[J]. J Endocrinol Invest, 2008, 31(7): 636-641.
  • 4Yamanaka K, Xu B, Suganuma I, et al. Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture[J]. Fertil Steril, 2012, 97(2):477-482. DOI: 10.1016/j.fertnstert.2011.11.005.
  • 5Shimizu Y, Mira S, Takeuchi T, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial ceils in a spheroid culture system[J]. Steroids, 2011, 76(1-2):60-67. DOI: 10.1016/j.steroids.2010.08.010.
  • 6Katayama H, Katayama T, Uematsu K, et al. Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model[J]. Hum Reprod, 2010, 25 (11):2851-2858. DOI: 10.1093/humrep/deq241.
  • 7Miyashita M, Koga K, Takamura M, et al. Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis[J]. Gynecol Endocrinol, 2014, 30(9):644-648. DOI: 10.3109/ 09513590.2014.911279.
  • 8Hayashi A, Tanabe A, Kawabe S, et al. Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis[J]. J Ovarian Res, 2012, 5(1):31. DOI: 10.1186/1757-2215-5-31.
  • 9Ichioka M, Mira S, Shimizu Y, et al. Dienogest, a syntheticprogestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells [J]. J Steroid Biochem Mol Biol, 2015, 147:103-110. DOI: 10.1016/j.jsbmb.2014.12.008.
  • 10K~hler G, G~retzlehner G, Amon I. Therapy of endometriosis with dienogest[J]. Zentralbl Gynakol, 1987, 109(12):795-801.

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