重组金丝雀痘病毒载体疫苗研制进展

The Status Progress in the Research of Recombinant Vaccine Based on Canarypox Virus

金丝雀痘病毒(canarypox virus,CNPV)引起的雀痘是一种禽类传染性疾病。CNPV感染后可在宿主体内诱导细胞、体液和黏膜免疫应答,经过改造可开发为一种候选疫苗载体,其可表达病毒和寄生虫的多种蛋白,因此,研制重组CNPV载体疫苗进行免疫预防具有重要的经济意义。国外学者已构建了多种类似疫苗,如马流感病毒(equine influenza virus,EIV)、犬瘟热病毒(canine distemper virus,CDV)、麻疹病毒(measles virus,MV)、尼帕病毒(Nipah virus,NiV)、艾滋病毒(human immunodeficiency virus type 1,HIV-1)、非洲马病病毒4型(African horse sickness virus type 4,AHSV-4)、蓝舌病毒17型(bluetongue virus serotype 17,BTV-17)、丙型肝炎病毒(hepatitis C virus,HCV)、巨细胞病毒(cytomelovirus,CMV)、狂犬病毒(rabies virus)和婴儿利什曼原虫(Leishmania infantum)等。概述了CNPV载体介导的病原体疫苗的构建及其免疫机制等方面的研制现状,旨在为病毒和寄生虫病的免疫预防提供理论依据。

Poxvirus caused by canarypox virus(CNPV)is an infectious disease of poultry,CNPV infection can induce cellular,humoral and mucosal immune responses in the host.It can be remade as a candidate vaccine vector after modification,which can express multiple proteins of viruses and parasites.Therefore,it is of great economic importance to develop recombinant CNPV vector vaccine for immune prevention.The foreign scholars have constructed a variety of similar vaccines,such as equine influenza virus(EIV),canine distemper virus(CDV),measles virus(MV),Nipah virus(NiV),human immunodeficiency virus type 1(HIV-1),African horse sickness virus type 4(AHSV-4),bluetongue virus serotype 17(BTV-17),hepatitis C virus(HCV),cytomelovirus(CMV),rabies virus and Leishmania infantum and so on.This article summerized the status in the research of construction and immune mechanism of CNPV-based vaccines,aiming to provide a theoretical basis for the immune prevention of viruses and parasitic diseases.