长链非编码RNA对肿瘤免疫的调控作用

Roles of long noncoding RNAs in regulating tumor immunity

长链非编码RNA(long non-coding RNAs, lncRNAs)能调控干细胞分化、生长发育、衰老以及肿瘤等多种生理及病理过程.近年来研究发现, lncRNAs在肿瘤免疫应答过程中发挥重要的调控作用.一方面, lncRNAs可以影响肿瘤细胞抗原呈递和抑制性信号表达以及招募免疫抑制性细胞;另一方面, lncRNAs可以影响免疫细胞(包括固有免疫细胞和适应性免疫细胞)的功能和命运.此外, lncRNAs还可作为肿瘤细胞和免疫细胞之间的交流信使调控肿瘤免疫应答.本文旨在梳理lncRNAs在肿瘤免疫过程中的作用及机制,从而为提高肿瘤免疫治疗效果提供新的思路和策略.

Long noncoding RNAs(lnc RNAs) are engaged in many physiological and pathological processes, including stem cell differentiation,growth, and development, senescence and cancer, etc. Recent studies have begun to unravel the roles of lnc RNAs in tumor immunity as well. lnc RNAs are involved in regulating tumor cells through downregulating tumor antigens, upregulating inhibitory signals, and recruiting immunosuppressive cells. Additionally, the functions and cell fates of immune cells(both innate and adaptive) are influenced by lnc RNAs. Furthermore, lnc RNAs act as messengers to mediate the communication between tumor and immune cells. In this review, we summarized the functions and mechanisms of lnc RNAs in regulating tumor immunity and provided new ideas and strategies for improving the impacts of tumor immunotherapy.